Decreased expression of reelin receptor VLDLR in peripheral lymphocytes of drug-naive schizophrenic patients.

Decreased expression of reelin receptor VLDLR in peripheral lymphocytes of drug-naive schizophrenic patients. Research Abstract Details 

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Decreased expression of reelin receptor VLDLR in peripheral lymphocytes of drug-naive schizophrenic patients. Abstract Text:

Katsuaki Suzuki,Kazuhiko Nakamura,Yasuhide Iwata,Yoshimoto Sekine,Masayoshi Kawai,Genichi Sugihara,Kenji J Tsuchiya,Shiro Suda,Hideo Matsuzaki,Nori Takei,Kenji Hashimoto,Norio Mori,Katsuaki Suzuki,Kazuhiko Nakamura,Yasuhide Iwata,Yoshimoto Sekine,Masayoshi Kawai,Genichi Sugihara,Kenji J Tsuchiya,Shiro Suda,Hideo Matsuzaki,Nori Takei,Kenji Hashimoto,Norio Mori,Katsuaki Suzuki,Kazuhiko Nakamura,Yasuhide Iwata,Yoshimoto Sekine,Masayoshi Kawai,Genichi Sugihara,Kenji J Tsuchiya,Shiro Suda,Hideo Matsuzaki,Nori Takei,Kenji Hashimoto,Norio Mori,

Reelin, a secretory protease that plays major roles in neurodevelopment and synaptic plasticity, may also play a role in the pathogenesis of schizophrenia. The present study was undertaken to examine whether the expression of two receptors for reelin, very low-density lipoprotein receptor (VLDLR) and apolipoprotein E receptor type 2 (ApoER2), were abnormal in peripheral blood lymphocytes of schizophrenic patients. In this study, we measured the mRNA levels of VLDLR and ApoER2 in blood lymphocytes from patients with schizophrenia (drug-naive patients (n=20) and medicated patients (n=20)) and age-and gender-matched healthy controls (n=40) using quantitative real-time RT-PCR. Furthermore, we examined the correlation between mRNA levels and clinical variables in patients. Levels of VLDLR mRNA in drug-naive, unmedicated patients with schizophrenia were significantly lower than those of controls. In contrast, levels of ApoER2 mRNA in drug-naive patients did not differ from those of controls, although the levels of ApoER2 mRNA in medicated patients were significantly lower than those of controls. Interestingly, levels of VLDLR mRNA in drug-naive patients showed significant increases with respect to baseline after six months of antipsychotic treatment, whereas levels of ApoER2 mRNA were significantly lower than baseline after six months of treatment. In all patients, there was a negative correlation between VLDLR mRNA levels and the severity of clinical symptoms. Our findings suggest that peripheral VLDLR mRNA levels may serve as a reliable peripheral biological marker of schizophrenia, and that the reelin-VLDLR/ApoER2 signaling pathway plays a role in the pathophysiology of schizophrenia.

Decreased expression of reelin receptor VLDLR in peripheral lymphocytes of drug-naive schizophrenic patients. Publishing Authors By Initials

K Suzuki,K Nakamura,Y Iwata,Y Sekine,M Kawai,G Sugihara,KJ Tsuchiya,S Suda,H Matsuzaki,N Takei,K Hashimoto,N Mori,K Suzuki,K Nakamura,Y Iwata,Y Sekine,M Kawai,G Sugihara,KJ Tsuchiya,S Suda,H Matsuzaki,N Takei,K Hashimoto,N Mori,K Suzuki,K Nakamura,Y Iwata,Y Sekine,M Kawai,G Sugihara,KJ Tsuchiya,S Suda,H Matsuzaki,N Takei,K Hashimoto,N Mori,

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Decreased expression of reelin receptor VLDLR in peripheral lymphocytes of drug-naive schizophrenic patients. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Schizophrenia research

VOLUME: 98

Page Numbers: 148-56

Journal Abbreviation: Schizophr. Res.

ISSN: 0920-9964

DAY: 23

MONTH: 10

YEAR: 2007

Decreased expression of reelin receptor VLDLR in peripheral lymphocytes of drug-naive schizophrenic patients. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Decreased expression of reelin receptor VLDLR in peripheral lymphocytes of drug-naive schizophrenic patients.

AFFILIATION: Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan.

Country: Netherlands

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MEDLINETA: Schizophr Res

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