Decreased expression levels of CD22 and L-selectin on peripheral blood B lymphocytes from patients with bullous pemphigoid.

Decreased expression levels of CD22 and L-selectin on peripheral blood B lymphocytes from patients with bullous pemphigoid. Research Abstract Details 

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Decreased expression levels of CD22 and L-selectin on peripheral blood B lymphocytes from patients with bullous pemphigoid. Abstract Text:

Makoto Inaoki,Takeshi Echigo,Hiroaki Hayashi,Tetsuya Nagaoka,Minoru Hasegawa,Kazuhiko Takehara,Wataru Fujimoto,Thomas F Tedder,Shinichi Sato,

Bullous pemphigoid (BP), an autoimmune subepidermal-blistering disease of the elderly, is caused by antibodies against BP antigens at the epidermal basement membrane zone (BMZ). CD22 is a B lymphocyte specific response regulator, which is down-regulated after B-cell activation. Old CD22-deficient mice produce class-switched autoantibodies. To assess the role of CD22 in the pathogenesis of BP, we examined CD22 expression on B cells from BP patients and correlated its expression with clinical parameters. B cell expression of CD22 was 20% lower in BP patients when compared to healthy control subjects. In addition, B cells from BP patients showed decreased expression of L-selectin, which is an indicator of leukocyte activation, and CD22 expression levels were correlated with L-selectin expression. These results suggest that the decreased CD22 expression may be associated with the activation of B cells in BP. CD22 expression levels in BP patients did not correlate with the levels of anti-epidermal BMZ antibodies, and old CD22-deficient mice did not develop the anti-epidermal BMZ antibody. These results suggest that a decrease in CD22 expression may not be associated with BP-specific antibody production.

Decreased expression levels of CD22 and L-selectin on peripheral blood B lymphocytes from patients with bullous pemphigoid. Publishing Authors By Initials

M Inaoki,T Echigo,H Hayashi,T Nagaoka,M Hasegawa,K Takehara,W Fujimoto,TF Tedder,S Sato,

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Decreased expression levels of CD22 and L-selectin on peripheral blood B lymphocytes from patients with bullous pemphigoid. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of autoimmunity

VOLUME: 27

Page Numbers: 196-202

Journal Abbreviation: J. Autoimmun.

ISSN: 0896-8411

DAY: 18

MONTH: 10

YEAR: 2006

Decreased expression levels of CD22 and L-selectin on peripheral blood B lymphocytes from patients with bullous pemphigoid. Information

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LANGUAGE: eng

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AFFILIATION: Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13-1 Takaramachi, Kanazawa, Ishikawa 920-8641, Japan; Department of Dermatology, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama 701-0192, Japan.

Country: England

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MEDLINETA: J Autoimmun

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