Decreased DOC-2/DAB2 expression in urothelial carcinoma of the bladder.

Decreased DOC-2/DAB2 expression in urothelial carcinoma of the bladder. Research Abstract Details 

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Decreased DOC-2/DAB2 expression in urothelial carcinoma of the bladder. Abstract Text:

Jose A Karam,Shahrokh F Shariat,Hong-Ying Huang,Rey-Chen Pong,Raheela Ashfaq,Ellen Shapiro,Yair Lotan,Arthur I Sagalowsky,Xue-Ru Wu,Jer-Tsong Hsieh,

PURPOSE: DOC-2/DAB2 (differentially expressed in ovarian carcinoma-2/disabled-2), a potential tumor suppressor gene, is underexpressed in several cancers. Little is known about the expression of this gene in urothelial carcinoma of the bladder (UCB). We profiled DOC-2/DAB2 expression in mouse and human normal and neoplastic urothelia. EXPERIMENTAL DESIGN: Immunohistochemical staining for DOC-2/DAB2 was carried out on tissue specimens from two transgenic mouse models with urothelium-specific molecular alterations and on a tissue microarray containing cores from 9 normal controls, 44 patients who underwent transurethral resection of the bladder tumor (TURBT), 195 patients who underwent radical cystectomy for UCB, and 39 lymph nodes with metastatic UCB. RESULTS: Normal mouse urothelium stained uniformly with DOC-2/DAB2. Weaker staining was observed in low-grade, superficial papillary bladder tumors from transgenic mice harboring constitutively active Ha-Ras, whereas carcinoma in situ-like lesions and high-grade bladder tumors from transgenic mice expressing a SV40 T antigen completely lacked DOC-2/DAB2 expression. In human tissues, DOC-2/DAB2 expression was decreased in 11% of normal bladder specimens, 59% of TURBT specimens, 65% of radical cystectomy specimens, and 77% of the metastatic lymph node specimens. Decreased DOC-2/DAB2 expression was associated with advanced pathologic stage (P = 0.023), lymph node metastases (P = 0.050), and lymphovascular invasion (P < 0.001). In univariable, but not in multivariable analysis, decreased DOC-2/DAB2 was associated with an increased probability of bladder cancer recurrence (log-rank test, P = 0.020) and bladder cancer-specific mortality (log-rank test, P = 0.023). CONCLUSIONS: Decreased DOC-2/DAB2 expression seems to occur early in bladder tumorigenesis and becomes more prominent in advanced stages of UCB.

Decreased DOC-2/DAB2 expression in urothelial carcinoma of the bladder. Publishing Authors By Initials

JA Karam,SF Shariat,HY Huang,RC Pong,R Ashfaq,E Shapiro,Y Lotan,AI Sagalowsky,XR Wu,JT Hsieh,

For similar neoplasms: neoplasms by site: urogenital neoplasms: urologic neoplasms: urinary bladder neoplasms research abstracts see: neoplasms: neoplasms by site: urogenital neoplasms: urologic neoplasms: urinary bladder neoplasms research

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MEDLINE DATE:

Decreased DOC-2/DAB2 expression in urothelial carcinoma of the bladder. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Clinical cancer research : an official journal of

VOLUME: 13

Page Numbers: 4400-6

Journal Abbreviation: Clin. Cancer Res.

ISSN: 1078-0432

DAY: 1

MONTH: Aug

YEAR: 2007

Decreased DOC-2/DAB2 expression in urothelial carcinoma of the bladder. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9502500

Decreased DOC-2/DAB2 expression in urothelial carcinoma of the bladder. Keywords Mesh Terms:

KEYWORDS: Urinary Bladder Neoplasms

MESH TERMS: surgery

Chemical & Substance for Abstract: Decreased DOC-2/DAB2 expression in urothelial carcinoma of the bladder. Information

Substance Name: Tumor Markers, Biological

Registry Number: 0

Grant and Affiliation Information for Decreased DOC-2/DAB2 expression in urothelial carcinoma of the bladder.

AFFILIATION: Department of Urology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA.

Country: United States

AGENCY: United States NCRR

GRANT: K30-RR022269-08

ACRONYM: RR

MEDLINETA: Clin Cancer Res

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