Decomposition of S-nitrosocysteine via S- to N-transnitrosation.

Decomposition of S-nitrosocysteine via S- to N-transnitrosation. Research Abstract Details 

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Decomposition of S-nitrosocysteine via S- to N-transnitrosation. Abstract Text:

Lisa A Peterson,Tanja Wagener,Helmut Sies,Wilhelm Stahl,

S-nitrosothiols are thought to be important intermediates in nitric oxide signaling pathways. These compounds are unstable, in part, through their ability to donate NO. One model S-nitrosothiol, S-nitrosocysteine, is particularly unstable. Recently, it was proposed that this compound decomposed via intra and intermolecular transfer of the NO group from the sulfur to the nitrogen to form N-nitrosocysteine. This primary nitrosamine is expected to rapidly rearrange to ultimately form a reactive diazonium ion intermediate. To test this hypothesis, we demonstrated that thiirane-2-carboxylic acid is formed during the decomposition of S-nitrosocysteine at neutral pH. Acrylic acid was another product of this reaction. These results indicate that a small but significant amount of S-nitrosocysteine decomposes via S- to N-transnitrosation. The formation of a reactive intermediate in this process indicates the potential for this reaction to contribute to the toxicological properties of nitric oxide.

Decomposition of S-nitrosocysteine via S- to N-transnitrosation. Publishing Authors By Initials

LA Peterson,T Wagener,H Sies,W Stahl,

For similar inorganic chemicals: elements: chalcogens: sulfur research abstracts see: inorganic chemicals: elements: chalcogens: sulfur research

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Decomposition of S-nitrosocysteine via S- to N-transnitrosation. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Chemical research in toxicology

VOLUME: 20

Page Numbers: 721-3

Journal Abbreviation: Chem. Res. Toxicol.

ISSN: 0893-228X

DAY: 18

MONTH: 04

YEAR: 2007

Decomposition of S-nitrosocysteine via S- to N-transnitrosation. Information

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LANGUAGE: eng

NlmUniqueID: 8807448

Decomposition of S-nitrosocysteine via S- to N-transnitrosation. Keywords Mesh Terms:

KEYWORDS: Sulfur

MESH TERMS: chemistry

Chemical & Substance for Abstract: Decomposition of S-nitrosocysteine via S- to N-transnitrosation. Information

Substance Name: acrylic acid

Registry Number: 79-10-7

Grant and Affiliation Information for Decomposition of S-nitrosocysteine via S- to N-transnitrosation.

AFFILIATION: Division of Environmental Health Sciences and the Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA. peter431@umn.edu

Country: United States

AGENCY: United States NCI

GRANT: CA59887

ACRONYM: CA

MEDLINETA: Chem Res Toxicol

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