De novo synthesis of Tamiflu via a catalytic asymmetric ring-opening of meso-aziridines with TMSN3.

De novo synthesis of Tamiflu via a catalytic asymmetric ring-opening of meso-aziridines with TMSN3. Research Abstract Details 

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De novo synthesis of Tamiflu via a catalytic asymmetric ring-opening of meso-aziridines with TMSN3. Abstract Text:

Yuhei Fukuta,Tsuyoshi Mita,Nobuhisa Fukuda,Motomu Kanai,Masakatsu Shibasaki,

An asymmetric ring-opening reaction of meso-aziridines with TMSN3 was developed using a catalyst prepared from Y(OiPr)3 and chiral ligand 2 in a 1:2 ratio. Excellent enantioselectivity was realized from a wide range of substrates with a practical catalyst loading. The products were efficiently converted to enantiomerically enriched 1,2-diamines, which are versatile chiral building blocks for pharmaceuticals and chiral ligands. This reaction was applied to a catalytic asymmetric synthesis of Tamiflu, a very important anti-influenza drug containing a chiral 1,2-diamino functionality.

De novo synthesis of Tamiflu via a catalytic asymmetric ring-opening of meso-aziridines with TMSN3. Publishing Authors By Initials

Y Fukuta,T Mita,N Fukuda,M Kanai,M Shibasaki,

For similar organic chemicals: organosilicon compounds: trimethylsilyl compounds research abstracts see: organic chemicals: organosilicon compounds: trimethylsilyl compounds research

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De novo synthesis of Tamiflu via a catalytic asymmetric ring-opening of meso-aziridines with TMSN3. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of the American Chemical Society

VOLUME: 128

Page Numbers: 6312-3

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 17

MONTH: May

YEAR: 2006

De novo synthesis of Tamiflu via a catalytic asymmetric ring-opening of meso-aziridines with TMSN3. Information

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LANGUAGE: eng

NlmUniqueID: 7503056

De novo synthesis of Tamiflu via a catalytic asymmetric ring-opening of meso-aziridines with TMSN3. Keywords Mesh Terms:

KEYWORDS: Trimethylsilyl Compounds

MESH TERMS: chemistry

Chemical & Substance for Abstract: De novo synthesis of Tamiflu via a catalytic asymmetric ring-opening of meso-aziridines with TMSN3. Information

Substance Name: Trimethylsilyl Compounds

Registry Number: 0

Grant and Affiliation Information for De novo synthesis of Tamiflu via a catalytic asymmetric ring-opening of meso-aziridines with TMSN3.

AFFILIATION: Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan.

Country: United States

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MEDLINETA: J Am Chem Soc

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