Day 6 estradiol level predicts cycle cancellation among poor responder patients undergoing in vitro fertilization-embryo transfer cycles using a gonadotropin-releasing hormone agonist flare regimen.

Day 6 estradiol level predicts cycle cancellation among poor responder patients undergoing in vitro fertilization-embryo transfer cycles using a gonadotropin-releasing hormone agonist flare regimen. Research Abstract Details 

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Day 6 estradiol level predicts cycle cancellation among poor responder patients undergoing in vitro fertilization-embryo transfer cycles using a gonadotropin-releasing hormone agonist flare regimen. Abstract Text:

PURPOSE: To compare two GnRHa flare protocols among poor responders undergoing IVF-ET and to evaluate if a Day 6 estradiol level can predict outcome. METHODS: Retrospective analyses of GnRHa flare IVF cycles among poor responders. Group A ("miniflare," N = 36) 40 microg GnRHa s.c. b.i.d. from Day 3; Group B ("standard flare," N = 24) 1 mg GnRHa on Days 2-3; 0.5 mg GnRHa from Day 4. ROC analysis was performed to find a Day 6 estradiol value that is predictive of cycle outcome. RESULTS: With the standard flare, patients required less gonadotropins and tended to have fewer cancellations and higher pregnancy rates. A Day 6 estradiol level < or = 75 pg/mL was predictive of cycle cancellation, but not of pregnancy outcome. CONCLUSIONS: Standard GnRHa flare offers some advantages over the miniflare. Day 6 estradiol < or = 75 pg/mL is predictive of cycle cancellation. When the estradiol level is low on Day 6 (no flare), early cancellation should be considered.

Day 6 estradiol level predicts cycle cancellation among poor responder patients undergoing in vitro fertilization-embryo transfer cycles using a gonadotropin-releasing hormone agonist flare regimen. Publishing Authors By Initials

For similar reproductive and urinary physiology: reproduction: menstrual cycle research abstracts see: reproductive and urinary physiology: reproduction: menstrual cycle research

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Day 6 estradiol level predicts cycle cancellation among poor responder patients undergoing in vitro fertilization-embryo transfer cycles using a gonadotropin-releasing hormone agonist flare regimen. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of assisted reproduction and genetics

VOLUME: 19

Page Numbers: 349-53

Journal Abbreviation: J. Assist. Reprod. Genet.

ISSN: 1058-0468

DAY: 18

MONTH: Jul

YEAR: 2002

Day 6 estradiol level predicts cycle cancellation among poor responder patients undergoing in vitro fertilization-embryo transfer cycles using a gonadotropin-releasing hormone agonist flare regimen. Information

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LANGUAGE: eng

NlmUniqueID: 9206495

Day 6 estradiol level predicts cycle cancellation among poor responder patients undergoing in vitro fertilization-embryo transfer cycles using a gonadotropin-releasing hormone agonist flare regimen. Keywords Mesh Terms:

KEYWORDS: Menstrual Cycle

MESH TERMS: drug effects

Chemical & Substance for Abstract: Day 6 estradiol level predicts cycle cancellation among poor responder patients undergoing in vitro fertilization-embryo transfer cycles using a gonadotropin-releasing hormone agonist flare regimen. Information

Substance Name: LHRH, Ala(6)-Gly(10)-ethylamide-

Registry Number: 79561-22-1

Grant and Affiliation Information for Day 6 estradiol level predicts cycle cancellation among poor responder patients undergoing in vitro fertilization-embryo transfer cycles using a gonadotropin-releasing hormone agonist flare regimen.

AFFILIATION: Department of Obstetrics and Gynecology, Albert Einstein College of Medicine, Bronx, New York 10461, USA. pkovcs@aol.com

Country: United States

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MEDLINETA: J Assist Reprod Genet

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