Daunorubicin and daunorubicinol tissue concentrations in gastric cancer patients after local administration of a liposomal preparation.

Daunorubicin and daunorubicinol tissue concentrations in gastric cancer patients after local administration of a liposomal preparation. Research Abstract Details 

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Daunorubicin and daunorubicinol tissue concentrations in gastric cancer patients after local administration of a liposomal preparation. Abstract Text:

M Furlanut,G de Manzoni,F Pasini,S Tasselli,A Tomezzoli,D Poz,L Franceschi,M Furlanut,G de Manzoni,F Pasini,S Tasselli,A Tomezzoli,D Poz,L Franceschi,M Furlanut,G de Manzoni,F Pasini,S Tasselli,A Tomezzoli,D Poz,L Franceschi,

BACKGROUND: In order to study a model that maximizes gastric cancer tissue and lymph node exposure to antineoplastic drugs while simultaneously reducing their systemic bioavailability, we implemented a preliminary investigation of the disposition of a daunorubicin liposomal preparation (D) in gastric cancer patients by means of gastric submucosa injection. METHOD: After a dose finding study, 12 patients (candidates for gastric resection because of gastric cancer) were studied by administering two doses of 50 mg of D (the highest tolerated dose) 1 week before surgery. RESULTS: Mean tissue concentrations at surgery were higher in cancer, normal non-injected peritumoral mucosa, and lymph node tissues than in serum or urine, in which there were only trace concentrations. While epigastric pain and histological modifications (inflammation and thickening of the gastric layers) were manifest in patients treated with 75 mg doses in the dose finding session, no clinical signs or symptoms of toxicity were recorded in those administered with 50 mg doses. CONCLUSIONS: Local administration of D may allow it to reach high concentrations in normal non-injected peritumoral mucosa, and lymph nodes, while simultaneously avoiding significant systemic exposure and toxicity. This procedure could merit further investigation, in view of a possible use of anthracyclines against metastatic diffusion through the lymphatic system in gastric cancer patients who are candidates for gastric resection.

Daunorubicin and daunorubicinol tissue concentrations in gastric cancer patients after local administration of a liposomal preparation. Publishing Authors By Initials

M Furlanut,G de Manzoni,F Pasini,S Tasselli,A Tomezzoli,D Poz,L Franceschi,M Furlanut,G de Manzoni,F Pasini,S Tasselli,A Tomezzoli,D Poz,L Franceschi,M Furlanut,G de Manzoni,F Pasini,S Tasselli,A Tomezzoli,D Poz,L Franceschi,

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Daunorubicin and daunorubicinol tissue concentrations in gastric cancer patients after local administration of a liposomal preparation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Pharmacological research : the official journal of

VOLUME: 56

Page Numbers: 344-9

Journal Abbreviation: Pharmacol. Res.

ISSN: 1043-6618

DAY: 24

MONTH: 08

YEAR: 2007

Daunorubicin and daunorubicinol tissue concentrations in gastric cancer patients after local administration of a liposomal preparation. Information

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LANGUAGE: eng

NlmUniqueID: 8907422

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AFFILIATION: Institute of Clinical Pharmacology and Toxicology, DPMSC, University of Udine, Italy. mario.furlanut@med.uniud.it

Country: England

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MEDLINETA: Pharmacol Res

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