Daryamides A-C, weakly cytotoxic polyketides from a marine-derived actinomycete of the genus Streptomyces strain CNQ-085.

Daryamides A-C, weakly cytotoxic polyketides from a marine-derived actinomycete of the genus Streptomyces strain CNQ-085. Research Abstract Details 

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Daryamides A-C, weakly cytotoxic polyketides from a marine-derived actinomycete of the genus Streptomyces strain CNQ-085. Abstract Text:

Ratnakar N Asolkar,Paul R Jensen,Christopher A Kauffman,William Fenical,

In the course of our continuing search for new antitumor-antibiotics from marine-derived actinomycete bacteria, four new cytotoxic compounds, designated as daryamides A (1), B (2), and C (3) and (2E,4E)-7-methylocta-2,4-dienoic acid amide (4), were isolated from the culture broth of a marine-derived Streptomyces strain CNQ-085. The structures of these new compounds were assigned by detailed interpretation of spectroscopic data. The relative configuration of 1 was determined by comprehensive NMR analysis, while the absolute configuration of 1 was determined as 4S,5R using the modified Mosher method. The daryamides show weak to moderate cytotoxic activity against the human colon carcinoma cell line HCT-116 and very weak antifungal activities against Candida albicans.

Daryamides A-C, weakly cytotoxic polyketides from a marine-derived actinomycete of the genus Streptomyces strain CNQ-085. Publishing Authors By Initials

RN Asolkar,PR Jensen,CA Kauffman,W Fenical,

For similar cells: cells, cultured: tumor cells, cultured research abstracts see: cells: cells, cultured: tumor cells, cultured research

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Daryamides A-C, weakly cytotoxic polyketides from a marine-derived actinomycete of the genus Streptomyces strain CNQ-085. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of natural products

VOLUME: 69

Page Numbers: 1756-9

Journal Abbreviation: J. Nat. Prod.

ISSN: 0163-3864

DAY: 3

MONTH: Dec

YEAR: 2006

Daryamides A-C, weakly cytotoxic polyketides from a marine-derived actinomycete of the genus Streptomyces strain CNQ-085. Information

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LANGUAGE: eng

NlmUniqueID: 7906882

Daryamides A-C, weakly cytotoxic polyketides from a marine-derived actinomycete of the genus Streptomyces strain CNQ-085. Keywords Mesh Terms:

KEYWORDS: Tumor Cells, Cultured

MESH TERMS: chemistry

Chemical & Substance for Abstract: Daryamides A-C, weakly cytotoxic polyketides from a marine-derived actinomycete of the genus Streptomyces strain CNQ-085. Information

Substance Name: daryamide C

Registry Number: 0

Grant and Affiliation Information for Daryamides A-C, weakly cytotoxic polyketides from a marine-derived actinomycete of the genus Streptomyces strain CNQ-085.

AFFILIATION: Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California-San Diego, La Jolla, CA 92093-0204, USA.

Country: United States

AGENCY: United States NCI

GRANT: CA 66775

ACRONYM: CA

MEDLINETA: J Nat Prod

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