DARPP-32 involvement in the photic pathway of the circadian system.

DARPP-32 involvement in the photic pathway of the circadian system. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

DARPP-32 involvement in the photic pathway of the circadian system. Abstract Text:

Lily Yan,Jessica M Bobula,Per Svenningsson,Paul Greengard,Rae Silver,

The multifunctional regulator of protein kinases and phosphatases dopamine- and cAMP-regulated phosphoprotein of 32 kDa (DARPP-32) is an important molecular target of the dopamine signaling pathway. In the present study, we investigated the possible involvement of DARPP-32 regulation in the circadian system using DARPP-32 knock-out (KO) mice. These mice showed normal entrainment to a 12 h light/dark cycle and free run in constant darkness with a period similar to that of wild-type controls. After light exposure, however, the behavioral phase-delay response and the expression of light-induced clock gene mPer2 were attenuated in the DARPP-32 KO mice. Attenuated phase delays were also seen in animals bearing a point mutation in DARPP-32 at the PKA (Thr34) but not at the casein kinase I (Ser130) phosphorylation site. We next examined DARPP-32 expression in the retina and intergeniculate leaflet (IGL), both of which convey light information to the suprachiasmatic nucleus (SCN), the locus of a master circadian clock, and in the SCN itself. DARPP-32 was expressed in the retina but not in the IGL or the SCN. The results indicate that DARPP-32 is involved in the retinal pathway transmitting photic information that resets the circadian clock.

DARPP-32 involvement in the photic pathway of the circadian system. Publishing Authors By Initials

L Yan,JM Bobula,P Svenningsson,P Greengard,R Silver,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

DARPP-32 involvement in the photic pathway of the circadian system. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The Journal of neuroscience : the official journal

VOLUME: 26

Page Numbers: 9434-8

Journal Abbreviation:

ISSN: 1529-2401

DAY: 13

MONTH: Sep

YEAR: 2006

DARPP-32 involvement in the photic pathway of the circadian system. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8102140

DARPP-32 involvement in the photic pathway of the circadian system. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: DARPP-32 involvement in the photic pathway of the circadian system. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for DARPP-32 involvement in the photic pathway of the circadian system.

AFFILIATION: Department of Psychology, Columbia University, New York, New York 10027, USA.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Neurosci

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

DARPP-32 involvement in the photic pathway of the circadian system Related Publications

• A role for androgens in regulating circadian behavior and the suprachiasmatic nucleus.
• A short half-life GFP mouse model for analysis of suprachiasmatic nucleus organization.
• Activation of AKT and nuclear accumulation of wild type TP53 and MDM2 in anal squamous cell carcinoma.
• Applications of magnetic resonance spectroscopy to tinnitus research: initial data, current issues, and future perspectives.
• Astrocytic stem cells in the adult brain.
• Cellular localization and function of DARPP-32 in the rodent retina.
• DARPP-32 involvement in the photic pathway of the circadian system.
• Decoding High Level Signals for Asynchronous Brain Machine interfaces.
• Differences in the growth of paired Ugandan isolates of Mycobacterium tuberculosis within human mononuclear phagocytes correlate with epidemiological evidence of strain virulence.
• Differential induction and localization of mPer1 and mPer2 during advancing and delaying phase shifts.
• Dopamine and serotonin metabolism in response to chronic administration of fluvoxamine and haloperidol combined treatment.
• Down-regulation of collagen and connective tissue growth factor expression with hepatocyte growth factor in lung fibroblasts from white scleroderma patients via two signaling pathways.
• Expression of Period genes: rhythmic and nonrhythmic compartments of the suprachiasmatic nucleus pacemaker.
• Fibromatosis of the appendix and cecum.
• Functional specificity among ribosomal proteins regulates gene expression.
• Gates and oscillators II: zeitgebers and the network model of the brain clock.
• Gene expression changes in peripheral mononuclear cells from schizophrenic patients treated with a combination of antipsychotic with fluvoxamine.
• Gene-hormone-environment interactions in the regulation of aggressive responses: elegant analysis of complex behavior.
• Impairment of the antifibrotic effect of hepatocyte growth factor in lung fibroblasts from African Americans: possible role in systemic sclerosis.
• Introduction to "communicating with the schizophrenic superego revisited: a new technique".
• Pamela Silver.
• Ratio imaging: practical considerations for measuring intracellular Ca2+ and pH in living cells.
• Rational design of memory in eukaryotic cells.
• Resetting the brain clock: time course and localization of mPER1 and mPER2 protein expression in suprachiasmatic nuclei during phase shifts.
• Retail prices of essential drugs in Brazil: an international comparison.
• Risk of heparin-induced thrombocytopenia from heparin-bonded vascular prostheses.
• Temporal and spatial expression patterns of canonical clock genes and clock-controlled genes in the suprachiasmatic nucleus.
• The details bedevil DCOR.
• The role of extracellular matrix in CNS regeneration.
• Transcriptional regulation at the nuclear pore complex.