Dapsone-induced peripheral neuropathy. Case report and review.

Dapsone-induced peripheral neuropathy. Case report and review. Research Abstract Details 

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Dapsone-induced peripheral neuropathy. Case report and review. Abstract Text:

A severe motor and a minor sensory neuropathy developed in a man being treated with dapsone (4,4'-diaminodiphenylsulfone) for dermatitis herpetiformis. He had received dapsone for 16 years before any signs of neurotoxicity became evident. Electrodiagnostic and clinical features were consistent with an axonal neuropathy. Clinical characteristics of dapsone-induced neuropathy include a motor neuropathy affecting the extremities, usual onset within five years after the initiation of dapsone therapy, dapsone dosage usually equal to or greater than 300 mg/day, and, almost always, complete recovery from the neuropathy after dapsone-dose reduction or withdrawal. The patient was found to be a slow acetylator of sulfamethazine, and therefore is a slow acetylator of dapsone. An HLA typing was done on the patient. New cases of dapsone-induced neuropathy should be HLA typed and have acetylation profiles in an attempt to identify future high-risk patients. This case is noteworthy for the length of time of dapsone usage (16 years) and the low daily dosage of dapsone (100 mg) taken prior to the development of neuropathy.

Dapsone-induced peripheral neuropathy. Case report and review. Publishing Authors By Initials

For similar nervous system diseases: neuromuscular diseases: peripheral nervous system diseases research abstracts see: nervous system diseases: neuromuscular diseases: peripheral nervous system diseases research

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Dapsone-induced peripheral neuropathy. Case report and review. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Archives of dermatology

VOLUME: 120

Page Numbers: 356-9

Journal Abbreviation: Arch Dermatol

ISSN: 0003-987X

DAY: 17

MONTH: Mar

YEAR: 1984

Dapsone-induced peripheral neuropathy. Case report and review. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372433

Dapsone-induced peripheral neuropathy. Case report and review. Keywords Mesh Terms:

KEYWORDS: Peripheral Nervous System Diseases

MESH TERMS: chemically induced

Chemical & Substance for Abstract: Dapsone-induced peripheral neuropathy. Case report and review. Information

Substance Name: Dapsone

Registry Number: 80-08-0

Grant and Affiliation Information for Dapsone-induced peripheral neuropathy. Case report and review.

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Country: UNITED STATES

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MEDLINETA: Arch Dermatol

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