Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.

Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens. Research Abstract Details 

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Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens. Abstract Text:

Jun Xu,Charles W Saunders,Ping Hu,Raymond A Grant,Teun Boekhout,Eiko E Kuramae,James W Kronstad,Yvonne M Deangelis,Nancy L Reeder,Kevin R Johnstone,Meredith Leland,Angela M Fieno,William M Begley,Yiping Sun,Martin P Lacey,Tanuja Chaudhary,Thomas Keough,Lien Chu,Russell Sears,Bo Yuan,Thomas L Dawson,Jun Xu,Charles W Saunders,Ping Hu,Raymond A Grant,Teun Boekhout,Eiko E Kuramae,James W Kronstad,Yvonne M Deangelis,Nancy L Reeder,Kevin R Johnstone,Meredith Leland,Angela M Fieno,William M Begley,Yiping Sun,Martin P Lacey,Tanuja Chaudhary,Thomas Keough,Lien Chu,Russell Sears,Bo Yuan,Thomas L Dawson,

Fungi in the genus Malassezia are ubiquitous skin residents of humans and other warm-blooded animals. Malassezia are involved in disorders including dandruff and seborrheic dermatitis, which together affect >50% of humans. Despite the importance of Malassezia in common skin diseases, remarkably little is known at the molecular level. We describe the genome, secretory proteome, and expression of selected genes of Malassezia globosa. Further, we report a comparative survey of the genome and secretory proteome of Malassezia restricta, a close relative implicated in similar skin disorders. Adaptation to the skin environment and associated pathogenicity may be due to unique metabolic limitations and capabilities. For example, the lipid dependence of M. globosa can be explained by the apparent absence of a fatty acid synthase gene. The inability to synthesize fatty acids may be complemented by the presence of multiple secreted lipases to aid in harvesting host lipids. In addition, an abundance of genes encoding secreted hydrolases (e.g., lipases, phospholipases, aspartyl proteases, and acid sphingomyelinases) was found in the M. globosa genome. In contrast, the phylogenetically closely related plant pathogen Ustilago maydis encodes a different arsenal of extracellular hydrolases with more copies of glycosyl hydrolase genes. M. globosa shares a similar arsenal of extracellular hydrolases with the phylogenetically distant human pathogen, Candida albicans, which occupies a similar niche, indicating the importance of host-specific adaptation. The M. globosa genome sequence also revealed the presence of mating-type genes, providing an indication that Malassezia may be capable of sex.

Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens. Publishing Authors By Initials

J Xu,CW Saunders,P Hu,RA Grant,T Boekhout,EE Kuramae,JW Kronstad,YM Deangelis,NL Reeder,KR Johnstone,M Leland,AM Fieno,WM Begley,Y Sun,MP Lacey,T Chaudhary,T Keough,L Chu,R Sears,B Yuan,TL Dawson,J Xu,CW Saunders,P Hu,RA Grant,T Boekhout,EE Kuramae,JW Kronstad,YM Deangelis,NL Reeder,KR Johnstone,M Leland,AM Fieno,WM Begley,Y Sun,MP Lacey,T Chaudhary,T Keough,L Chu,R Sears,B Yuan,TL Dawson,

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Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 104

Page Numbers: 18730-5

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 1091-6490

DAY: 13

MONTH: 11

YEAR: 2007

Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens. Information

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LANGUAGE: eng

NlmUniqueID: 7505876

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Grant and Affiliation Information for Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens.

AFFILIATION: Procter & Gamble Co., Miami Valley Innovation Center, Cincinnati, OH 45253-8707, USA.

Country: United States

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MEDLINETA: Proc Natl Acad Sci U S A

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