DA-6034, a Derivative of Flavonoid, Prevents and Ameliorates Dextran Sulfate Sodium-Induced Colitis and Inhibits Colon Carcinogenesis.

DA-6034, a Derivative of Flavonoid, Prevents and Ameliorates Dextran Sulfate Sodium-Induced Colitis and Inhibits Colon Carcinogenesis. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

DA-6034, a Derivative of Flavonoid, Prevents and Ameliorates Dextran Sulfate Sodium-Induced Colitis and Inhibits Colon Carcinogenesis. Abstract Text:

Su Youn Nam,Joo Sung Kim,Jung Mogg Kim,Jong Yeul Lee,Nayoung Kim,Hyun Chae Jung,In Sung Song,

Previously, we have shown that DA-6034, a synthetic derivative of flavonoid eupatilin, inhibited NF-kappaB activation in colon epithelial cells and prevented trinitrobenzene sulfonic acid-induced rat colitis. The aim of this study was to investigate the preventive and therapeutic effect of DA-6034 on dextran sulfate sodium (DSS)-induced colitis and on inflammation-related cancer. C57BL/6 mice were given 4% DSS for 5 days with and without DA-6034 in the acute preventive model. In the acute therapeutic model, mice were given 4% DSS for 5 days followed by rectal administration of DA-6034. Colitis was quantified by body weight, disease activity index (DAI), colon length, and histology. In the inflammation-related cancer model, mice were given a single intraperitoneal injection of azoxymethane, then three cycles of 2% DSS for 5 days, then 2 weeks of free water consumption. Apoptosis was determined by in situ terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling assay, and the expression of Ki-67, phospho-kappaB kinase alpha (IKKalpha), and COX-2 were evaluated by immunohistochemistry. In both the acute preventive and acute therapeutic models, DA-6034 significantly attenuated DSS-induced weight loss, an increase in DAI, and a shortening of colon length. DA-6034-treated mice maintained crypt architecture and revealed a scanty infiltration of inflammatory cells in both the preventive and therapeutic models. In the inflammation-related cancer model, DA-6034 reduced the number of colon tumors and ameliorated weight loss and shortening of colon length. DA-6034 strongly enhanced apoptosis and inhibited the expression of COX-2 and phospho-IKKalpha in inflammation-related colon cancer models. Our results suggest that DA-6034 prevents acute murine colitis and inhibits inflammation-related colon carcinogenesis. DA-6034 could be a potential therapeutic agent for inflammatory bowel disease.

DA-6034, a Derivative of Flavonoid, Prevents and Ameliorates Dextran Sulfate Sodium-Induced Colitis and Inhibits Colon Carcinogenesis. Publishing Authors By Initials

SY Nam,JS Kim,JM Kim,JY Lee,N Kim,HC Jung,IS Song,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

DA-6034, a Derivative of Flavonoid, Prevents and Ameliorates Dextran Sulfate Sodium-Induced Colitis and Inhibits Colon Carcinogenesis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Experimental biology and medicine (Maywood, N.J.)

VOLUME: 233

Page Numbers: 180-91

Journal Abbreviation: Exp. Biol. Med. (Maywood)

ISSN: 1535-3702

DAY: 28

MONTH: Feb

YEAR: 2008

DA-6034, a Derivative of Flavonoid, Prevents and Ameliorates Dextran Sulfate Sodium-Induced Colitis and Inhibits Colon Carcinogenesis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100973463

DA-6034, a Derivative of Flavonoid, Prevents and Ameliorates Dextran Sulfate Sodium-Induced Colitis and Inhibits Colon Carcinogenesis. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: DA-6034, a Derivative of Flavonoid, Prevents and Ameliorates Dextran Sulfate Sodium-Induced Colitis and Inhibits Colon Carcinogenesis. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for DA-6034, a Derivative of Flavonoid, Prevents and Ameliorates Dextran Sulfate Sodium-Induced Colitis and Inhibits Colon Carcinogenesis.

AFFILIATION: Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul, 110-744, Korea. jooskim@snu.ac.kr.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Exp Biol Med (Maywood)

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

DA-6034, a Derivative of Flavonoid, Prevents and Ameliorates Dextran Sulfate Sodium-Induced Colitis and Inhibits Colon Carcinogenesis Related Publications

• Study of gerontological nursing curriculum.
• [Allotransplantation of cultured fetal parathyroid gland cells in treating patients with hypoparathyroidism]
• [Changes in desiccation tolerance and cell ultrastructures of wampee axes induced by progressively raising sucrose concentration of culture medium.]
• [Choices of proper words and word collocations in English medical papers]
• [Coagulation factor VII levels in uremic patients and theirs influence factors]
• [Dental implants in patients with Type 2 diabetes mellitus: a clinical study.]
• [Determination of LF-VD refining furnace slag by X ray fluorescence spectrometry]
• [Effects of 6-BA on cluster root formation and organic acid exudation in white lupin grown under phosphorus deficiency.]
• [Effects of cooking oil fume condensate on cellular immunity and immunosurveillance in mice]
• [Effects of marine bacteria on the growth and toxin production of red-tide algae under different pH and salinities]
• [Establishment of high-yield suspension cell line of Curcuma zedoaria (Berg.) Rosc and study on the volatile oil synthesis-controlling with precursors]
• [Identification of edible mushrooms by Fourier transform infrared spectroscopy]
• [In vitro infection of human megakaryocyte precursors by human cytomegalovirus (HCMV) and the antiviral effect of HCMV antisense oligonucleotides.]
• [LC troubleshooting-solvent life and degradation]
• [NO may function in the downstream of H2O2 in ABA-induced stomatal closure in Vicia faba L.]
• [Regulation role of reactive oxygen species and mitogen-activated protein kinases in plant stress signaling]
• [Role of kaliuretic peptide and molar ratio of kaliuretic peptide/atrial natriuretic peptide in atrial fibrillation]
• [Role of tissue factor pathway inhibitor-2 in ovarian tumor migration and invasion]
• [Simultaneous determination of eight phthalate esters in PVC by GC]
• [Spectral study of podophyllotoxin and its derivatives]
• [Study of the effect of TF/FVIIa complex on the expression of u-PAR mRNA in human ovarian cancer]
• [Study on the interaction between CP and DNA]
• [Synaptonemal complexes analysis in male fertility impairment in two men]
• [Synthesis and characterization of mixed ligand complexes rare earth with 2,3-dimethoxylbenzoic acid and 1,10-phenanthroline]
• [Synthesis of mixed complexes of lanthanum with 2,2-bipyridyl and 1,10-phenanthroline and study of the interaction of the complexes with DNA]
• [The cluster analysis of trace elements in Fructus Cnidii from different region]
• [The effects of tissue factor/activated factor VII complex on the invasion and metastasis of human ovarian cancer.]
• [The psychological impact of mastectomy on women with breast cancer]
• [Three-dimensional volumetric display--a new application of frequency up-conversion]
• [XPS and MS study of phosphorous heterocycle compounds]