d-Asb11 is an essential mediator of canonical Delta-Notch signalling.

d-Asb11 is an essential mediator of canonical Delta-Notch signalling. Research Abstract Details 

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d-Asb11 is an essential mediator of canonical Delta-Notch signalling. Abstract Text:

In canonical Delta-Notch signalling, expression of Delta activates Notch in neighbouring cells, leading to downregulation of Delta in these cells. This process of lateral inhibition results in selection of either Delta-signalling cells or Notch-signalling cells. Here we show that d-Asb11 is an important mediator of this lateral inhibition. In zebrafish embryos, morpholino oligonucleotide (MO)-mediated knockdown of d-Asb11 caused repression of specific Delta-Notch elements and their transcriptional targets, whereas these were induced when d-Asb11 was misexpressed. d-Asb11 also activated legitimate Notch reporters cell-non-autonomously in vitro and in vivo when co-expressed with a Notch reporter. However, it repressed Notch reporters when expressed in Delta-expressing cells. Consistent with these results, d-Asb11 was able to specifically ubiquitylate and degrade DeltaA both in vitro and in vivo. We conclude that d-Asb11 is a component in the regulation of Delta-Notch signalling, important in fine-tuning the lateral inhibition gradients between DeltaA and Notch through a cell non-autonomous mechanism.

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d-Asb11 is an essential mediator of canonical Delta-Notch signalling. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Nature cell biology

VOLUME: 10

Page Numbers: 1190-8

Journal Abbreviation: Nat. Cell Biol.

ISSN: 1476-4679

DAY: 7

MONTH: 09

YEAR: 2008

d-Asb11 is an essential mediator of canonical Delta-Notch signalling. Information

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LANGUAGE: eng

NlmUniqueID: 100890575

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Grant and Affiliation Information for d-Asb11 is an essential mediator of canonical Delta-Notch signalling.

AFFILIATION: Deptartment of Cell Biology, University Medical Center Groningen, University of Groningen, A. Deusinglaan 1, NL-9713 AV Groningen, The Netherlands.

Country: England

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MEDLINETA: Nat Cell Biol

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