Cytotoxicity of Fas ligand against lymphoma cells with radiation-induced Fas antigen.

Cytotoxicity of Fas ligand against lymphoma cells with radiation-induced Fas antigen. Research Abstract Details 

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Cytotoxicity of Fas ligand against lymphoma cells with radiation-induced Fas antigen. Abstract Text:

Y Ogawa,A Nishioka,I Kubonishi,T Inomata,S Yoshida,S Kataoka,

Fas antigen, also termed APO-1 or CD95, is a transmembrane protein and a member of the tumor necrosis factor receptor/nerve growth factor receptor superfamily which mediates apoptosis upon oligomerization. The Fas/Fas ligand system is considered to be a key regulator of apoptosis. Recently, we have demonstrated that Fas antigen expression is induced by low-dose irradiation of some types of lymphomas, and we also demonstrated that irradiation-induced Fas antigen expression increased with the passage of time until peaking at 48 h after irradiation in CML-C1, CML-C2, DL-40, and DL-95 cell lines. In this study, we also examined the potential cytotoxicity of Fas ligand peptide against several types of lymphoma/leukemia cell lines that showed induction of Fas antigen expression under irradiation. Flow cytometry analysis was performed at 6, 24 and 48 h after irradiation. Samples (1 x10(6) cells/ml) from irradiated and non-irradiated cells of each cell line were incubated with or without 5 microg/ml of Fas ligand peptide for 2 h at 37 degrees C in a humidified atmosphere of 5% carbon dioxide (CO2) in air. The killing effect of Fas ligand against cell lines of CML-C1, DL-40, and DL-95 were clearly identified as the percentage of cells with Fas antigen expression induced by irradiation. Concerning HD-70 cell line, for which soluble Fas antigen has been identified, the killing effects were clearly observed in samples pre-treated with PBS washings. To our knowledge, this is the first report describing a possible application of the Fas/Fas ligand system in treatment of certain types of malignancies in which Fas antigen is inducible by irradiation.

Cytotoxicity of Fas ligand against lymphoma cells with radiation-induced Fas antigen. Publishing Authors By Initials

Y Ogawa,A Nishioka,I Kubonishi,T Inomata,S Yoshida,S Kataoka,

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Cytotoxicity of Fas ligand against lymphoma cells with radiation-induced Fas antigen. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: International journal of molecular medicine

VOLUME: 2

Page Numbers: 435-6

Journal Abbreviation: Int. J. Mol. Med.

ISSN: 1107-3756

DAY: 14

MONTH: Oct

YEAR: 1998

Cytotoxicity of Fas ligand against lymphoma cells with radiation-induced Fas antigen. Information

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LANGUAGE: eng

NlmUniqueID: 9810955

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Grant and Affiliation Information for Cytotoxicity of Fas ligand against lymphoma cells with radiation-induced Fas antigen.

AFFILIATION: Department of Radiology, Kochi Medical School, Nankoku, Kochi 783-8505, Japan.

Country: Greece

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MEDLINETA: Int J Mol Med

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