Cytotoxic ent-abietane diterpenes from Gelonium aequoreum.

Cytotoxic ent-abietane diterpenes from Gelonium aequoreum. Research Abstract Details 

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Cytotoxic ent-abietane diterpenes from Gelonium aequoreum. Abstract Text:

Chia-Lin Lee,Fang-Rong Chang,Pei-Wen Hsieh,Michael-Y Chiang,Chin-Chung Wu,Zih-You Huang,Yu-Hsuan Lan,Mei Chen,Kuo-Hsiung Lee,Hsin-Fu Yen,Wen-Chun Hung,Yang-Chang Wu,

Seventeen ent-abietane diterpenes, including gelomulides K-X (1-14), and three known compounds, were isolated from a dichloromethane-soluble extract of Gelonium aequoreum through bioassay-guided fractionation. Their structures were identified by spectroscopic methods, and stereochemistry was confirmed by X-ray crystallographic analysis, CD spectral data, and Mosher's method. The isolates were evaluated for in vitro cytotoxic activity, and compounds 1 and 3 showed moderate cytotoxicity against lung (A549), breast (MDA-MB-231 and MCF7), and liver (HepG2) cancer cell lines.

Cytotoxic ent-abietane diterpenes from Gelonium aequoreum. Publishing Authors By Initials

CL Lee,FR Chang,PW Hsieh,MY Chiang,CC Wu,ZY Huang,YH Lan,M Chen,KH Lee,HF Yen,WC Hung,YC Wu,

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Cytotoxic ent-abietane diterpenes from Gelonium aequoreum. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Phytochemistry

VOLUME: 69

Page Numbers: 276-87

Journal Abbreviation: Phytochemistry

ISSN: 0031-9422

DAY: 21

MONTH: 08

YEAR: 2007

Cytotoxic ent-abietane diterpenes from Gelonium aequoreum. Information

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LANGUAGE: eng

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AFFILIATION: Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan.

Country: United States

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MEDLINETA: Phytochemistry

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