Cytotoxic edema: mechanisms of pathological cell swelling.

Cytotoxic edema: mechanisms of pathological cell swelling. Research Abstract Details 

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Cytotoxic edema: mechanisms of pathological cell swelling. Abstract Text:

Danny Liang,Sergei Bhatta,Volodymyr Gerzanich,J Marc Simard,

Cerebral edema is caused by a variety of pathological conditions that affect the brain. It is associated with two separate pathophysiological processes with distinct molecular and physiological antecedents: those related to cytotoxic (cellular) edema of neurons and astrocytes, and those related to transcapillary flux of Na+ and other ions, water, and serum macromolecules. In this review, the authors focus exclusively on the first of these two processes. Cytotoxic edema results from unchecked or uncompensated influx of cations, mainly Na+, through cation channels. The authors review the different cation channels that have been implicated in the formation of cytotoxic edema of astrocytes and neurons in different pathological states. A better understanding of these molecular mechanisms holds the promise of improved treatments of cerebral edema and of the secondary injury produced by this pathological process.

Cytotoxic edema: mechanisms of pathological cell swelling. Publishing Authors By Initials

D Liang,S Bhatta,V Gerzanich,JM Simard,

For similar nervous system: neurons research abstracts see: nervous system: neurons research

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Cytotoxic edema: mechanisms of pathological cell swelling. Journal Published:

PUBLICATION TYPE: Review

Journal: Neurosurgical focus

VOLUME: 22

Page Numbers: E2

Journal Abbreviation:

ISSN: 1092-0684

DAY: 15

MONTH: 05

YEAR: 2007

Cytotoxic edema: mechanisms of pathological cell swelling. Information

Number of References: 174

LANGUAGE: eng

NlmUniqueID: 100896471

Cytotoxic edema: mechanisms of pathological cell swelling. Keywords Mesh Terms:

KEYWORDS: Neurons

MESH TERMS: pathology

Chemical & Substance for Abstract: Cytotoxic edema: mechanisms of pathological cell swelling. Information

Substance Name: Ion Channels

Registry Number: 0

Grant and Affiliation Information for Cytotoxic edema: mechanisms of pathological cell swelling.

AFFILIATION: Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland 21201-1595, USA.

Country: United States

AGENCY: United States NINDS

GRANT: NS048260

ACRONYM: NS

MEDLINETA: Neurosurg Focus

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