Cytotoxic clerodane diterpenoids and their hydrolysis products from Casearia nigrescens from the rainforest of Madagascar.

Cytotoxic clerodane diterpenoids and their hydrolysis products from Casearia nigrescens from the rainforest of Madagascar. Research Abstract Details 

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Cytotoxic clerodane diterpenoids and their hydrolysis products from Casearia nigrescens from the rainforest of Madagascar. Abstract Text:

Russell B Williams,Andrew Norris,James S Miller,Chris Birkinshaw,Fidy Ratovoson,Rabodo Andriantsiferana,Vincent E Rasamison,David G I Kingston,

Bioassay-guided fractionation of the cytotoxic leaf and flower extract of Casearia nigrescens led to the isolation of four new clerodane diterpenoids, designated caseanigrescens A-D (1-4). These compounds were subject to hydrolysis to dialdehydes when stored in CDCl3. The structures of compounds 1-4 were determined using 1D and 2D NMR spectroscopy. All four compounds showed moderate cytotoxicity to the A2780 human ovarian cancer cell line, with an IC50 range of 0.83-1.4 microM.

Cytotoxic clerodane diterpenoids and their hydrolysis products from Casearia nigrescens from the rainforest of Madagascar. Publishing Authors By Initials

RB Williams,A Norris,JS Miller,C Birkinshaw,F Ratovoson,R Andriantsiferana,VE Rasamison,DG Kingston,

For similar plants: plants, medicinal research abstracts see: plants: plants, medicinal research

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Cytotoxic clerodane diterpenoids and their hydrolysis products from Casearia nigrescens from the rainforest of Madagascar. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of natural products

VOLUME: 70

Page Numbers: 206-9

Journal Abbreviation: J. Nat. Prod.

ISSN: 0163-3864

DAY: 3

MONTH: Feb

YEAR: 2007

Cytotoxic clerodane diterpenoids and their hydrolysis products from Casearia nigrescens from the rainforest of Madagascar. Information

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LANGUAGE: eng

NlmUniqueID: 7906882

Cytotoxic clerodane diterpenoids and their hydrolysis products from Casearia nigrescens from the rainforest of Madagascar. Keywords Mesh Terms:

KEYWORDS: Plants, Medicinal

MESH TERMS: chemistry

Chemical & Substance for Abstract: Cytotoxic clerodane diterpenoids and their hydrolysis products from Casearia nigrescens from the rainforest of Madagascar. Information

Substance Name: Diterpenes, Clerodane

Registry Number: 0

Grant and Affiliation Information for Cytotoxic clerodane diterpenoids and their hydrolysis products from Casearia nigrescens from the rainforest of Madagascar.

AFFILIATION: Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061-0212, USA.

Country: United States

AGENCY: United States FIC

GRANT: U01 TW000313

ACRONYM: TW

MEDLINETA: J Nat Prod

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