Cytotoxic and apoptotic activities of novel amino analogues of boswellic acids.

Cytotoxic and apoptotic activities of novel amino analogues of boswellic acids. Research Abstract Details 

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Cytotoxic and apoptotic activities of novel amino analogues of boswellic acids. Abstract Text:

Bhahwal A Shah,Ajay Kumar,Pankaj Gupta,Madhunika Sharma,Vijay K Sethi,Ajit K Saxena,Jaswant Singh,Ghulam N Qazi,Subhash C Taneja,Bhahwal A Shah,Ajay Kumar,Pankaj Gupta,Madhunika Sharma,Vijay K Sethi,Ajit K Saxena,Jaswant Singh,Ghulam N Qazi,Subhash C Taneja,

4-Amino analogues prepared from beta-boswellic acid and 11-keto-beta-boswellic acid, wherein the carboxyl group in ursane nucleus was replaced by an amino function via Curtius reaction, displayed improved cytotoxicity than the parent molecules. The same molecules also exhibited apoptotic activity by inducing DNA fragmentation.

Cytotoxic and apoptotic activities of novel amino analogues of boswellic acids. Publishing Authors By Initials

BA Shah,A Kumar,P Gupta,M Sharma,VK Sethi,AK Saxena,J Singh,GN Qazi,SC Taneja,BA Shah,A Kumar,P Gupta,M Sharma,VK Sethi,AK Saxena,J Singh,GN Qazi,SC Taneja,

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Cytotoxic and apoptotic activities of novel amino analogues of boswellic acids. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Bioorganic & medicinal chemistry letters

VOLUME: 17

Page Numbers: 6411-6

Journal Abbreviation: Bioorg. Med. Chem. Lett.

ISSN: 0960-894X

DAY: 10

MONTH: 10

YEAR: 2007

Cytotoxic and apoptotic activities of novel amino analogues of boswellic acids. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Cytotoxic and apoptotic activities of novel amino analogues of boswellic acids.

AFFILIATION: Indian Institute of Integrative Medicine (CSIR), Canal Road, Jammu Tawi 180001, India.

Country: England

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MEDLINETA: Bioorg Med Chem Lett

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