Cytotoxic and Antihaptotactic beauvericin analogues from precursor-directed biosynthesis with the insect pathogen Beauveria bassiana ATCC 7159.

Cytotoxic and Antihaptotactic beauvericin analogues from precursor-directed biosynthesis with the insect pathogen Beauveria bassiana ATCC 7159. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Cytotoxic and Antihaptotactic beauvericin analogues from precursor-directed biosynthesis with the insect pathogen Beauveria bassiana ATCC 7159. Abstract Text:

Yuquan Xu,Jixun Zhan,E M Kithsiri Wijeratne,Anna M Burns,A A Leslie Gunatilaka, ,

Precursor-directed biosynthesis was used to produce analogues of the cyclic depsipeptide mycotoxin beauvericin (1) using the filamentous fungus Beauveria bassiana ATCC 7159. Feeding 30 analogues of D-2-hydroxyisovalerate and L-phenylalanine, the natural 2-hydroxycarboxylic acid and amino acid precursors of beauvericin, led to the biosynthesis of novel beauvericins. Six of these were isolated and characterized, and their cytotoxicity and directional cell migration (haptotaxis) inhibitory activity against the metastatic prostate cancer cell line PC-3M were evaluated. Replacement of one, two, or all three of the D-2-hydroxyisovalerate constituents in beauvericin (1) with 2-hydroxybutyrate moieties (beauvericins G(1-3), compounds 2-4) caused a parallel decline of cell migration inhibitory activity and cytotoxicity, suggesting a requirement for a branched side chain for both of these biological activities at the corresponding positions of beauvericins. Replacement of one, two, or all three N-methyl-L-phenylalanine residues of beauvericin with N-methyl-L-3-fluorophenylalanine moieties (beauvericins H(1-3), compounds 5-7) increased cytotoxicity without affecting antihaptotactic activity.

Cytotoxic and Antihaptotactic beauvericin analogues from precursor-directed biosynthesis with the insect pathogen Beauveria bassiana ATCC 7159. Publishing Authors By Initials

Y Xu,J Zhan,EM Wijeratne,AM Burns,AA Gunatilaka,I ,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Cytotoxic and Antihaptotactic beauvericin analogues from precursor-directed biosynthesis with the insect pathogen Beauveria bassiana ATCC 7159. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of natural products

VOLUME: 70

Page Numbers: 1467-71

Journal Abbreviation: J. Nat. Prod.

ISSN: 0163-3864

DAY: 6

MONTH: 09

YEAR: 2007

Cytotoxic and Antihaptotactic beauvericin analogues from precursor-directed biosynthesis with the insect pathogen Beauveria bassiana ATCC 7159. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7906882

Cytotoxic and Antihaptotactic beauvericin analogues from precursor-directed biosynthesis with the insect pathogen Beauveria bassiana ATCC 7159. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Cytotoxic and Antihaptotactic beauvericin analogues from precursor-directed biosynthesis with the insect pathogen Beauveria bassiana ATCC 7159. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Cytotoxic and Antihaptotactic beauvericin analogues from precursor-directed biosynthesis with the insect pathogen Beauveria bassiana ATCC 7159.

AFFILIATION: SW Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, The University of Arizona, Tucson, Arizona 85706-6800, USA.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Nat Prod

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Cytotoxic and Antihaptotactic beauvericin analogues from precursor-directed biosynthesis with the insect pathogen Beauveria bassiana ATCC 7159 Related Publications

• Achilles tendon reconstruction after electrical injury with a neurotized cross-leg fillet flap.
• Age-dependent changes of auditory evoked potentials--effect of task difficulty.
• COE-pak and TEM-coe.
• Changes of EEG spectra and coherence following performance in a cognitive task in Alzheimer's disease.
• Comparative aspects of cortical neurogenesis in vertebrates.
• Contributions to dental asepsis. A review of the advantages and disadvantages, indications and contraindications of anti-bacterial aqueous solutions.
• Current surgical treatment of thoracic empyema in adults.
• Cytotoxic and Antihaptotactic beauvericin analogues from precursor-directed biosynthesis with the insect pathogen Beauveria bassiana ATCC 7159.
• Determination of long-lived Nb isotopes in nuclear power plant wastes.
• How to increase denture retention.
• Identification of molecular markers for aluminium tolerance in diploid oat through comparative mapping and QTL analysis.
• Influence of various surfactants on the antimicrobial activity of bromsalans and other ring-halogenated substances.
• Isolation of equine herpesvirus type 2 from foals, showing respiratory symptoms.
• Laser surgery of the vocal cord.
• N-Acetylcysteine as the magic bullet: Too good to be true.
• Omniflex and fixed prosthodontics...a review of recommendations.
• Our experience with PAO treatment in injured paraplegic and hemiparetic patients.
• Platelet sequestration in a vascular malformation of Klippel-Trenaunay syndrome.
• Raypaque--a preliminary report.
• Serotypes of Pasteurella haemolytica and Pasteurella trehalosi isolated from farm animals in Hungary.
• Severe Listeria meningoencephalitis in an infliximab-treated patient with Crohn's disease.
• Site preference of myxozoans in the kidneys of Hungarian fishes.
• Why temporary restorations should be radiopaque.
• [Experiences with the medical treatment of recurrent urinary incotinence after surgery.]
• [Experiences with the use of ceramic color paints]
• [POSTOPERATIVE RESULTS IN URINARY INCONTINENCE IN AGED WOMEN.]
• [Possibilities in the diagnosis of male fertility disorders]
• [Pregnancy and delivery complicated by Addison's disease.]
• [Simultaneous occurrence of diabetes insipidus & pregnancy.]
• [THE QUESTION OF THE OPERATIVE TREATMENT OF FUNCTIONAL URINARY INCONTINENCE IN WOMEN.]