Cytotoxic activity of some natural and synthetic ent-kauranes.

Cytotoxic activity of some natural and synthetic ent-kauranes. Research Abstract Details 

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Cytotoxic activity of some natural and synthetic ent-kauranes. Abstract Text:

Sergio Rosselli,Maurizio Bruno,Antonella Maggio,Gabriella Bellone,Tzu-Hsuan Chen,Kenneth F Bastow,Kuo-Hsiung Lee,

Atractyligenin (1) and several synthetic derivatives were tested and found to be active against tumor cell replication. Compound 1 was readily converted to the 2,15-diketo (3) or 15-keto (4) derivatives, which contain an alpha,beta-unsaturated ketone. Compounds 3 and 4 showed significant cytotoxic activity against all six tested cancer cell lines and were most potent against 1A9 ovarian cancer cells with EC50 values of 0.2 and 0.3 microM, respectively. These two 1-analogues are promising lead compounds for further investigation.

Cytotoxic activity of some natural and synthetic ent-kauranes. Publishing Authors By Initials

S Rosselli,M Bruno,A Maggio,G Bellone,TH Chen,KF Bastow,KH Lee,

For similar cells: cells, cultured: tumor cells, cultured research abstracts see: cells: cells, cultured: tumor cells, cultured research

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MEDLINE DATE:

Cytotoxic activity of some natural and synthetic ent-kauranes. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of natural products

VOLUME: 70

Page Numbers: 347-52

Journal Abbreviation: J. Nat. Prod.

ISSN: 0163-3864

DAY: 3

MONTH: Mar

YEAR: 2007

Cytotoxic activity of some natural and synthetic ent-kauranes. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7906882

Cytotoxic activity of some natural and synthetic ent-kauranes. Keywords Mesh Terms:

KEYWORDS: Tumor Cells, Cultured

MESH TERMS: chemistry

Chemical & Substance for Abstract: Cytotoxic activity of some natural and synthetic ent-kauranes. Information

Substance Name: Atractyloside

Registry Number: 17754-44-8

Grant and Affiliation Information for Cytotoxic activity of some natural and synthetic ent-kauranes.

AFFILIATION: Dipartimento di Chimica Organica, Università di Palermo, Viale delle Scienze, 90128 Palermo, Italy.

Country: United States

AGENCY: United States NCI

GRANT: CA 17625

ACRONYM: CA

MEDLINETA: J Nat Prod

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