Cytoplasmic decay of intergenic transcripts in Saccharomyces cerevisiae.

Cytoplasmic decay of intergenic transcripts in Saccharomyces cerevisiae. Research Abstract Details 

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Cytoplasmic decay of intergenic transcripts in Saccharomyces cerevisiae. Abstract Text:

Debrah M Thompson,Roy Parker,

Eukaryotes produce a number of noncoding transcripts from intergenic regions. In Saccharomyces cerevisiae, such cryptic unstable transcripts (CUTs) are thought to be degraded in the nucleus by a process involving polyadenylation and 3'-to-5' degradation by the nuclear exosome. In this work, we examine the degradation pathway of the RNA SRG1, which is produced from an intergenic region and contributes to the regulation of the SER3 gene by promoter occlusion during SRG1 transcription. Although there is some effect on SRG1 transcript levels when the nuclear exosome is compromised, the bulk of the SRG1 RNA is degraded in the cytoplasm by decapping and 5'-to-3' exonucleolytic digestion. Examination of other CUTs suggests that individual CUTs can be degraded by a variety of different mechanisms, including nuclear decay, cytoplasmic decapping and 5'-to-3' decay, and nonsense-mediated decay. Moreover, some CUTs appear to be associated with polyribosomes. These results indicate that some CUTs can be exported from the nucleus and enter translation before being degraded, identifying a potential mechanism for the evolution of new protein-encoding genes.

Cytoplasmic decay of intergenic transcripts in Saccharomyces cerevisiae. Publishing Authors By Initials

DM Thompson,R Parker,

For similar fungi: ascomycota: saccharomycetales: saccharomyces: saccharomyces cerevisiae research abstracts see: fungi: ascomycota: saccharomycetales: saccharomyces: saccharomyces cerevisiae research

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MEDLINE DATE:

Cytoplasmic decay of intergenic transcripts in Saccharomyces cerevisiae. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Molecular and cellular biology

VOLUME: 27

Page Numbers: 92-101

Journal Abbreviation: Mol. Cell. Biol.

ISSN: 0270-7306

DAY: 30

MONTH: 10

YEAR: 2006

Cytoplasmic decay of intergenic transcripts in Saccharomyces cerevisiae. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8109087

Cytoplasmic decay of intergenic transcripts in Saccharomyces cerevisiae. Keywords Mesh Terms:

KEYWORDS: Saccharomyces cerevisiae

MESH TERMS: physiology

Chemical & Substance for Abstract: Cytoplasmic decay of intergenic transcripts in Saccharomyces cerevisiae. Information

Substance Name: RNA

Registry Number: 63231-63-0

Grant and Affiliation Information for Cytoplasmic decay of intergenic transcripts in Saccharomyces cerevisiae.

AFFILIATION: Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, University of Arizona, Tucson, AZ 85721, USA. rrparker@email.arizona.edu.

Country: United States

AGENCY: United States NIGMS

GRANT: GM 45443

ACRONYM: GM

MEDLINETA: Mol Cell Biol

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