Cytomegalovirus encephalitis in a child with adenosine deaminase-deficient severe combined immune deficiency: a neuropathologic study.

Cytomegalovirus encephalitis in a child with adenosine deaminase-deficient severe combined immune deficiency: a neuropathologic study. Research Abstract Details 

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Cytomegalovirus encephalitis in a child with adenosine deaminase-deficient severe combined immune deficiency: a neuropathologic study. Abstract Text:

T Takano,M Zielenska,L E Becker,T Takano,M Zielenska,L E Becker,

Cytomegalovirus (CMV) encephalitis is exceptional in patients with genetically determined immune deficiency syndromes. Neuropathologic findings of CMV encephalitis were present at postmortem examination in a child we treated for severe combined immune deficiency. Cultured skin fibroblasts of this male infant revealed a deficiency of adenosine deaminase (ADA). Lacking a suitable bone marrow donor, we used transfusions of red blood cells as a source of ADA. However, the child developed encephalopathy and died at 16 months. The main neuropathologic findings were numerous, widely distributed inclusion-bearing and CMV antigen-positive cells; a complete lack of inflammatory reaction; and cell-to-cell fusion of infected cells reflecting the child's severely impaired immune response.

Cytomegalovirus encephalitis in a child with adenosine deaminase-deficient severe combined immune deficiency: a neuropathologic study. Publishing Authors By Initials

T Takano,M Zielenska,LE Becker,T Takano,M Zielenska,LE Becker,

For similar congenital, hereditary, and neonatal diseases and abnormalities: infant, newborn, diseases: severe combined immunodeficiency research abstracts see: congenital, hereditary, and neonatal diseases and abnormalities: infant, newborn, diseases: severe combined immunodeficiency research

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Cytomegalovirus encephalitis in a child with adenosine deaminase-deficient severe combined immune deficiency: a neuropathologic study. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Neuropediatrics

VOLUME: 29

Page Numbers: 151-4

Journal Abbreviation: Neuropediatrics

ISSN: 0174-304X

DAY: 16

MONTH: Jun

YEAR: 1998

Cytomegalovirus encephalitis in a child with adenosine deaminase-deficient severe combined immune deficiency: a neuropathologic study. Information

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LANGUAGE: eng

NlmUniqueID: 8101187

Cytomegalovirus encephalitis in a child with adenosine deaminase-deficient severe combined immune deficiency: a neuropathologic study. Keywords Mesh Terms:

KEYWORDS: Severe Combined Immunodeficiency

MESH TERMS: pathology

Chemical & Substance for Abstract: Cytomegalovirus encephalitis in a child with adenosine deaminase-deficient severe combined immune deficiency: a neuropathologic study. Information

Substance Name: Adenosine Deaminase

Registry Number: EC 3.5.4.4

Grant and Affiliation Information for Cytomegalovirus encephalitis in a child with adenosine deaminase-deficient severe combined immune deficiency: a neuropathologic study.

AFFILIATION: Department of Pathology, Hospital for Sick Children, Toronto, Ontario, Canada.

Country: GERMANY

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MEDLINETA: Neuropediatrics

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