Cytokines in candidiasis and aspergillosis.

Cytokines in candidiasis and aspergillosis. Research Abstract Details 

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Cytokines in candidiasis and aspergillosis. Abstract Text:

Both innate and T helper (Th) immunity play a central role in fungal infections. A bi-directional influence exists between the two compartments of the immune system, mainly occurring through cytokine production. On the one hand, protective Th1 or nonprotective Th2 cells mediate resistance or susceptibility to disseminated and localized fungal infections by secreting cytokines with activating or deactivating signals for effector phagocytic cells. On the other hand, cells of the innate immune system regulate the development of antifungal T helper responses by producing directive cytokines, such as interleukin (IL)-12 and IL-10. In experimental models of Candida albicans and Aspergillus fumigatus infections, the administration or neutralization of selective cytokines and the use of cytokine-deficient mice have revealed the existence of a hierarchical pattern of cytokine mediated regulation of antifungal Th cell development and effector function. A finely regulated balance of directive cytokines, rather than the relative absence of opposing cytokines, appears to be required for optimal development and maintenance of protective Th1 reactivity to fungi. Thus, it is conceivable that some cytokines may have beneficial or deleterious effects on infection, depending on the dose and timing of endogenous production or exogenous administration. A better understanding of the different, sometimes unexpected, roles of cytokines is required for their use in prophylaxis and therapy of fungal infections, either alone or in combination with antifungal agents.

Cytokines in candidiasis and aspergillosis. Publishing Authors By Initials

For similar biological phenomena, cell phenomena, and immunity: immunity: immunity, cellular research abstracts see: biological phenomena, cell phenomena, and immunity: immunity: immunity, cellular research

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Cytokines in candidiasis and aspergillosis. Journal Published:

PUBLICATION TYPE: Review

Journal: Current pharmaceutical biotechnology

VOLUME: 1

Page Numbers: 235-51

Journal Abbreviation: Curr Pharm Biotechnol

ISSN: 1389-2010

DAY: 12

MONTH: Nov

YEAR: 2000

Cytokines in candidiasis and aspergillosis. Information

Number of References: 136

LANGUAGE: eng

NlmUniqueID: 100960530

Cytokines in candidiasis and aspergillosis. Keywords Mesh Terms:

KEYWORDS: Immunity, Cellular

MESH TERMS: physiology

Chemical & Substance for Abstract: Cytokines in candidiasis and aspergillosis. Information

Substance Name: Cytokines

Registry Number: 0

Grant and Affiliation Information for Cytokines in candidiasis and aspergillosis.

AFFILIATION: Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy. mencacci@unipg.it

Country: Netherlands

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MEDLINETA: Curr Pharm Biotechnol

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