Cytokine secretion and latent herpes virus reactivation with 28 days of horizontal hypokinesia.

Cytokine secretion and latent herpes virus reactivation with 28 days of horizontal hypokinesia. Research Abstract Details 

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Cytokine secretion and latent herpes virus reactivation with 28 days of horizontal hypokinesia. Abstract Text:

Peter N Uchakin,Raymond P Stowe,Douglas Paddon-Jones,Brian W Tobin,Arny A Ferrando,Robert R Wolfe,

INTRODUCTION: Hypokinesia is associated with spaceflight and prolonged illnesses and may lead to secondary immune deficiency. METHODS: The distribution of immunocytes in whole blood, mitogen-induced cytokine secretion in vitro, Epstein-Barr virus (EBV) reactivation, and plasma cortisol levels were studied in 13 healthy volunteers subjected to a horizontal bed rest (BR) regime for 28 d. Samples were collected before the study, weekly during BR, and then 3-5 d after the regime ended. Additionally, subjects were treated with hydrocortisone on the 1st and 27th d of BR to simulate the hypercortisolemia that occurs during stress. RESULTS: The factors of 28-d BR regime accompanied by acute hypercortisolemia significantly decreased the relative and absolute number of total lymphocytes, CD3+ T-cells, T-helper subset, and monocytes, but increased the percentage of the CD8+ T-cells, and NK cells at the 4th wk compared with the baseline. A significant decrease in mitogen-activated secretion of IL-2, IFN-gamma, TNF-beta, IL-6, and IL-10 was registered at the same interval. Also, secretion of IL-2 and IFN-gamma declined at the 2nd week of the BR regime. Secretion of IL-4 was significantly higher at the 2nd and 3rd weeks compared with the baseline. A significant increase in the shedding of EBV DNA in saliva was observed as early as the 3rd wk of BR. CONCLUSIONS: Stress factors associated with BR significantly alter immune responsiveness in vitro and in vivo. Changes in the cytokine secretion and cytokine imbalance precede latent EBV reactivation. PHA/LPS-activated cytokine secretion in whole blood can be used as a test system for predicting latent virus activation.

Cytokine secretion and latent herpes virus reactivation with 28 days of horizontal hypokinesia. Publishing Authors By Initials

PN Uchakin,RP Stowe,D Paddon-Jones,BW Tobin,AA Ferrando,RR Wolfe,

For similar biological phenomena, cell phenomena, and immunity: biological phenomena: microbiologic phenomena: viral physiology: virus latency research abstracts see: biological phenomena, cell phenomena, and immunity: biological phenomena: microbiologic phenomena: viral physiology: virus latency research

PUBMED ID PMID:

MEDLINE DATE:

Cytokine secretion and latent herpes virus reactivation with 28 days of horizontal hypokinesia. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Aviation, space, and environmental medicine

VOLUME: 78

Page Numbers: 608-12

Journal Abbreviation:

ISSN: 0095-6562

DAY: 3

MONTH: Jun

YEAR: 2007

Cytokine secretion and latent herpes virus reactivation with 28 days of horizontal hypokinesia. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7501714

Cytokine secretion and latent herpes virus reactivation with 28 days of horizontal hypokinesia. Keywords Mesh Terms:

KEYWORDS: Virus Latency

MESH TERMS: physiology

Chemical & Substance for Abstract: Cytokine secretion and latent herpes virus reactivation with 28 days of horizontal hypokinesia. Information

Substance Name: Hydrocortisone

Registry Number: 50-23-7

Grant and Affiliation Information for Cytokine secretion and latent herpes virus reactivation with 28 days of horizontal hypokinesia.

AFFILIATION: Department of Internal Medicine, Mercer University School of Medicine, 1550 College Street, Macon, GA, USA. uchakin_pn@mercer.edu

Country: United States

AGENCY: United States NIGMS

GRANT: 5 R01 GM 57295

ACRONYM: GM

MEDLINETA: Aviat Space Environ Med

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