Cytokine release following recruitment maneuvers.

Cytokine release following recruitment maneuvers. Research Abstract Details 

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Cytokine release following recruitment maneuvers. Abstract Text:

Daniel Talmor,Todd Sarge,Anna Legedza,Carl R O'Donnell,Ray Ritz,Stephen H Loring,Atul Malhotra,Daniel Talmor,Todd Sarge,Anna Legedza,Carl R O'Donnell,Ray Ritz,Stephen H Loring,Atul Malhotra,Daniel Talmor,Todd Sarge,Anna Legedza,Carl R O'Donnell,Ray Ritz,Stephen H Loring,Atul Malhotra,

BACKGROUND: There are reports of rigors and/or clinical deterioration following recruitment maneuvers (RMs), leading us to question whether the use of sustained high-pressure inflation could lead to release of inflammatory mediators. METHODS: Prospective cohort study of 26 patients with ARDS receiving mechanical ventilation. A single RM was performed during which the mean airway pressure was increased to 40 cm H2O and held constant for a period of 30 s. The concentration of nine cytokines (interleukin [IL]-1, IL-6, IL-8, IL-10, tumor necrosis factor [TNF]-alpha, Fas ligand, vascular endothelial growth factor, TNF receptor 1, TNF receptor 2) was measured longitudinally at three time points: prior to initiation of the RM, 5 min after the RM, and 60 min after the RM. RESULTS: RMs were tolerated well from a hemodynamic perspective. Oxygenation improved as reflected by an increased Pao2/fraction of inspired oxygen (Fio2) ratio from 140+/-49 at baseline to 190+/-78 (mean+/-SD) at 5 min after the RM (p=0.01). At 60 min, the increase in Pao2/Fio2 ratio, to 172+/-76, was no longer significant (p=0.1). There were no important changes in the levels of any of the measured cytokines at 5 min or 60 min following RM as compared with the baseline levels. CONCLUSIONS: The results of our study demonstrate that recruitment maneuvers are well tolerated in patients with ARDS. Our data suggest no major hemodynamic or immunologic evidence of deterioration within the first hour of RM. In particular, cytokines, previously related to worsening lung injury and distal organ failure in patients with ARDS, are not elevated by use of an RM. Registered at: www.clinicaltrials.gov as NCT00127491.

Cytokine release following recruitment maneuvers. Publishing Authors By Initials

D Talmor,T Sarge,A Legedza,CR O'Donnell,R Ritz,SH Loring,A Malhotra,D Talmor,T Sarge,A Legedza,CR O'Donnell,R Ritz,SH Loring,A Malhotra,D Talmor,T Sarge,A Legedza,CR O'Donnell,R Ritz,SH Loring,A Malhotra,

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Cytokine release following recruitment maneuvers. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Chest

VOLUME: 132

Page Numbers: 1434-9

Journal Abbreviation:

ISSN: 0012-3692

DAY: 9

MONTH: 10

YEAR: 2007

Cytokine release following recruitment maneuvers. Information

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LANGUAGE: eng

NlmUniqueID: 231335

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Grant and Affiliation Information for Cytokine release following recruitment maneuvers.

AFFILIATION: Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, 1 Deaconess Rd, CC-470, Boston MA 02215, USA. dtalmor@bidmc.harvard.edu

Country: United States

AGENCY: United States NHLBI

GRANT: HL-52586

ACRONYM: HL

MEDLINETA: Chest

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