Cytokine production, activation marker, and skin homing receptor in children with atopic dermatitis and bronchial asthma.

Cytokine production, activation marker, and skin homing receptor in children with atopic dermatitis and bronchial asthma. Research Abstract Details 

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Cytokine production, activation marker, and skin homing receptor in children with atopic dermatitis and bronchial asthma. Abstract Text:

T cells are known to develop a critical role in the pathogenesis of atopic dermatitis (AD) and bronchial asthma. T cells involved in AD express the skin homing receptor CLA, but no lung homing receptor has been identified in bronchial asthma. We compared different cell markers and the cytokine production in T cells from children with AD or bronchial asthma. We studied the involvement of CLA+ and CLA- T-cell subpopulations in these diseases. We studied 20 children with acute AD lesions, 15 with mild persistent asthma, and 15 non-atopic controls. All patients were sensitized to house dust mite (DP) and evaluated during the acute phase. Total and specific IgE were measured by immunoassay and the expression of different cell markers and the cytokine production was analyzed by flow cytometry in peripheral blood mononuclear cells. Total IgE was significantly higher in AD children and IgE to DP in the asthmatic children. There was a significant increase in CD25+ CD4+ cells in asthmatic children and in HLA-DR+ CD4+ and HLA-DR+ CD8+ cells in AD. In the CD4+ subsets, there was an increase in IL-13, IL-5 and TNF-alpha in AD compared to controls, a decrease in IFN-gamma in asthmatic children compared to controls, and an increase in IL-13, IL5, IL2, TNF-alpha, and IFN-gamma in the AD compared to asthmatic children. Changes in cytokine production were mainly detected in CLA+ cells in AD and in CLA- cells in asthma. Differences exist in total and specific IgE, activation markers, and cytokine patterns between AD children and children with asthma, with the former expressing a Th2 pattern whereas in asthmatic children we only detected a decrease in IFN-gamma. Moreover, the subpopulations (CLA+ vs. CLA-) expressing these changes were different, indicating that the underlying mechanisms in the two diseases are not exactly the same.

Cytokine production, activation marker, and skin homing receptor in children with atopic dermatitis and bronchial asthma. Publishing Authors By Initials

For similar peptides: intercellular signaling peptides and proteins: cytokines: monokines: tumor necrosis factor-alpha research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: monokines: tumor necrosis factor-alpha research

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Cytokine production, activation marker, and skin homing receptor in children with atopic dermatitis and bronchial asthma. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Pediatric allergy and immunology : official public

VOLUME: 17

Page Numbers: 166-74

Journal Abbreviation: Pediatr Allergy Immunol

ISSN: 0905-6157

DAY: 28

MONTH: May

YEAR: 2006

Cytokine production, activation marker, and skin homing receptor in children with atopic dermatitis and bronchial asthma. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9106718

Cytokine production, activation marker, and skin homing receptor in children with atopic dermatitis and bronchial asthma. Keywords Mesh Terms:

KEYWORDS: Tumor Necrosis Factor-alpha

MESH TERMS: metabolism

Chemical & Substance for Abstract: Cytokine production, activation marker, and skin homing receptor in children with atopic dermatitis and bronchial asthma. Information

Substance Name: Interferon Type II

Registry Number: 82115-62-6

Grant and Affiliation Information for Cytokine production, activation marker, and skin homing receptor in children with atopic dermatitis and bronchial asthma.

AFFILIATION: Research Unit for Allergic Diseases, Allergic Service, Carlos Haya Hospital, Málaga, Spain.

Country: England

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MEDLINETA: Pediatr Allergy Immunol

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