Cytogenetic effects of low-dose radiation with different LET in human peripheral blood lymphocytes.

Cytogenetic effects of low-dose radiation with different LET in human peripheral blood lymphocytes. Research Abstract Details 

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Cytogenetic effects of low-dose radiation with different LET in human peripheral blood lymphocytes. Abstract Text:

E A Nasonova,N L Shmakova,O V Komova,L A Mel'nikova,T A Fadeeva,E A Krasavin,S Ritter,

Chromosome damage and the spectrum of aberrations induced by low doses of gamma-irradiation, X-rays and accelerated carbon ions (195 MeV/u, LET 16.6 keV/microm) in peripheral blood lymphocytes of four donors were studied. G0-lymphocytes were exposed to 1-100 cGy, stimulated by PHA, and analyzed for chromosome aberrations at 48 h post-irradiation by the metaphase method. A complex nonlinear dose-effect dependence was observed over the range of 1 to 50 cGy. At 1-7 cGy, the cells showed the highest radiosensitivity per unit dose (hypersensitivity, HRS), which was mainly due to chromatid-type aberration. According to the classical theory of aberration formation, chromatid-type aberrations should not be induced by irradiation of unstimulated lymphocytes. With increasing dose, the frequency of aberrations decreased significantly, and in some cases it even reached the control level. At above 50 cGy the dose-effect curves became linear. In this dose range, the frequency of chromatid aberrations remained at a low constant level, while the chromosome-type aberrations increased linearly with dose. The high yield of chromatid-type aberrations observed in our experiments at low doses confirms the idea that the molecular mechanisms which underlie the HRS phenotype may differ from the classical mechanisms of radiation-induced aberration formation. The data presented, as well as recent literature data on bystander effects and genetic instability expressed as chromatid-type aberrations on a chromosomal level, are discussed with respect to possible common mechanisms underlying all low-dose phenomena.

Cytogenetic effects of low-dose radiation with different LET in human peripheral blood lymphocytes. Publishing Authors By Initials

EA Nasonova,NL Shmakova,OV Komova,LA Mel'nikova,TA Fadeeva,EA Krasavin,S Ritter,

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Cytogenetic effects of low-dose radiation with different LET in human peripheral blood lymphocytes. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Radiation and environmental biophysics

VOLUME: 45

Page Numbers: 307-12

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ISSN: 0301-634X

DAY: 10

MONTH: 10

YEAR: 2006

Cytogenetic effects of low-dose radiation with different LET in human peripheral blood lymphocytes. Information

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LANGUAGE: eng

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AFFILIATION: Laboratory of Radiation Biology, Joint Institute for Nuclear Research, Dubna, 141980, Russia. nasonova@jinr.ru

Country: Germany

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MEDLINETA: Radiat Environ Biophys

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