Cytochrome P450s and cholesterol homeostasis.

Cytochrome P450s and cholesterol homeostasis. Research Abstract Details

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Cytochrome P450s and cholesterol homeostasis. Abstract Text:

Irina A Pikuleva,

By participating in pathways of cholesterol biosynthesis and elimination, different cytochrome P450 (P450 or CYP) enzymes play an important role in maintenance of cholesterol homeostasis. CYP51 is involved in cholesterol biosynthesis, whereas CYP 7A1, 27A1, 46A1, 7B1, 39A1, and 8B1 are the key enzymes in cholesterol catabolism to bile acids, the major route of cholesterol elimination in mammals. Cholesterol transformations to steroid hormones are also initiated by the P450 enzyme CYP11A1. Finally, one of the major drug-metabolizing P450s CYP3A4 seems to contribute to bile acid biosynthesis as well. The 9 P450s will be the focus of this review and assessed as drug targets for cholesterol lowering.

Cytochrome P450s and cholesterol homeostasis. Publishing Authors By Initials

IA Pikuleva,

For similar polycyclic compounds: steroids research abstracts see: polycyclic compounds: steroids research

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Cytochrome P450s and cholesterol homeostasis. Journal Published:

PUBLICATION TYPE: Review

Journal: Pharmacology & therapeutics

VOLUME: 112

Page Numbers: 761-73

Journal Abbreviation: Pharmacol. Ther.

ISSN: 0163-7258

DAY: 26

MONTH: 07

YEAR: 2006

Cytochrome P450s and cholesterol homeostasis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7905840

Cytochrome P450s and cholesterol homeostasis. Keywords Mesh Terms:

KEYWORDS: Steroids

MESH TERMS: biosynthesis

Chemical & Substance for Abstract: Cytochrome P450s and cholesterol homeostasis. Information

Substance Name: Cytochrome P-450 Enzyme System

Registry Number: 9035-51-2

Grant and Affiliation Information for Cytochrome P450s and cholesterol homeostasis.

AFFILIATION: Department of Pharmacology and Toxicology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-1031, USA. irpikule@utmb.edu

Country: England