Cystinuria in children and young adults: success of monitoring free-cystine urine levels.

Cystinuria in children and young adults: success of monitoring free-cystine urine levels. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Cystinuria in children and young adults: success of monitoring free-cystine urine levels. Abstract Text:

Luca Dello Strologo,Chiara Laurenzi,Antonia Legato,Anna Pastore,Luca Dello Strologo,Chiara Laurenzi,Antonia Legato,Anna Pastore,

Medical treatment of cystinuria is often disappointing. Patients undergo frequent surgery, which is often followed by early relapse. The aim of our study was to evaluate the efficacy of medical treatment of cystinuria, to prevent formation or to reduce the numbers and dimensions of renal stones. Twenty cystinuric patients were treated with a combined approach, including cystine-binding drugs. Free and bound urine cystine levels were measured every 4 months. Drug dosage was adjusted to maintain free urine cystine level below 100 micromol/mmol creatinine. Eighteen patients completed the study; detection of new stones was reduced from 0.28 per year to 0.03 per year, and, in six patients, the numbers and dimensions of pre-existing renal stones were reduced. Surgery was required in one subject, and no relapse was observed 12 months afterwards. The dosage required to achieve target levels was closely correlated with patient body weight: older children required a lower dose. Medical management of cystinuria is feasible. The treatment must be personalised in children, as the amount of drug required is strictly dependent on body size.

Cystinuria in children and young adults: success of monitoring free-cystine urine levels. Publishing Authors By Initials

L Dello Strologo,C Laurenzi,A Legato,A Pastore,L Dello Strologo,C Laurenzi,A Legato,A Pastore,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Cystinuria in children and young adults: success of monitoring free-cystine urine levels. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Pediatric nephrology (Berlin, Germany)

VOLUME: 22

Page Numbers: 1869-73

Journal Abbreviation: Pediatr. Nephrol.

ISSN: 0931-041X

DAY: 11

MONTH: 08

YEAR: 2007

Cystinuria in children and young adults: success of monitoring free-cystine urine levels. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8708728

Cystinuria in children and young adults: success of monitoring free-cystine urine levels. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Cystinuria in children and young adults: success of monitoring free-cystine urine levels. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Cystinuria in children and young adults: success of monitoring free-cystine urine levels.

AFFILIATION: Nephrology and Urology Department, Bambino Gesù Children's Hospital and Research Institute, Piazza S. Onofrio 4, 00165 Rome, Italy. dellostrologo@opbg.net

Country: Germany

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Pediatr Nephrol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Cystinuria in children and young adults: success of monitoring free-cystine urine levels Related Publications

• Adrenal axis function after high-dose steroid therapy for childhood acute lymphoblastic leukemia.
• Community service through the out-patient department.
• Computer-aided systematized approach to pediatric ECG analysis.
• Cystinuria in children and young adults: success of monitoring free-cystine urine levels.
• Definition and use of the experimental sensible parameters to characterize sensitivity and precision of a generic oxygen optical sensor.
• Exercise testing as a rehabilitative/training tool.
• Expected number of childhood cancers in Italy from 2001 to 2015.
• Head and neck cancer: the possible role of stem cells.
• Is there any possibility other than 'old myocardial infarction' for this 21-year-old heart?
• L-DOPA Preloading Increases the Uptake of Borophenylalanine in C6 Glioma Rat Model: A New Strategy to Improve BNCT Efficacy.
• Need as a determinant of perception.
• Non tuberculous mycobacteria infection of the parotid region: Two familiar cases.
• Optimization of R-(+)-alpha-terpineol production by the biotransformation of R-(+)-limonene.
• Parotid localized Castleman's disease and HHV-8 infection: a case report.
• Patchy sticky hard spheres: Analytical study and Monte Carlo simulations.
• Plant inner membrane anion channel (PIMAC) function in plant mitochondria.
• Production of biosurfactant by Bacillus subtilis LB5a on a pilot scale using cassava wastewater as substrate.
• Renal aplastic dysplasia and ipsilateral ectopic ureter obstructing the seminal via: a possible cause of male infertility: Part 2.
• Respiratory epithelial adenomatoid hamartoma of the maxillary sinus: case report.
• Sexual behavior of the American male; a special review of the Kinsey report.
• Social influences upon psychological trends.
• Spontaneous pneumothorax: medical or surgical treatment.
• Structural bases for recognition of Anp32/LANP proteins.
• The genetics of schizophrenia; a special review.
• ["Minorities" and "social control": two nodes in the social history of the cities]