Cysteine protease cathepsin X modulates immune response via activation of beta2 integrins.

Cysteine protease cathepsin X modulates immune response via activation of beta2 integrins. Research Abstract Details 

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Cysteine protease cathepsin X modulates immune response via activation of beta2 integrins. Abstract Text:

Cathepsin X is a lysosomal, cysteine dependent carboxypeptidase. Its expression is restricted to cells of the immune system, suggesting a function related to the processes of inflammatory and immune responses. It has been shown to stimulate macrophage antigen-1 (Mac-1) receptor-dependent adhesion and phagocytosis via interaction with integrin beta2 subunit. Here its potential role in regulating lymphocyte proliferation via Mac-1 and the other beta2 integrin receptor, lymphocyte function-associated antigen-1 (LFA-1) has been investigated. Cathepsin X has been shown to suppress proliferation of human peripheral blood mononuclear cells, by activation of Mac-1, known as a suppressive factor for lymphocyte proliferation. On the other hand, co-localization of cathepsin X and LFA-1 supports the role of cathepsin X in regulating LFA-1 activity, which enhances lymphocyte proliferation. As shown by fluorescence resonance energy transfer, using U-937 and Jurkat cells transfected with alpha(L)-mCFP and beta2-mYFP, recombinant cathepsin X directly activates LFA-1. The activation was confirmed by increased binding of monoclonal antibody 24, recognizing active LFA-1. We demonstrate that cathepsin X is involved in the regulation of two beta2 integrin receptors, LFA-1 and Mac-1, which exhibit opposing roles in lymphocyte activation.

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Cysteine protease cathepsin X modulates immune response via activation of beta2 integrins. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Immunology

VOLUME: 124

Page Numbers: 76-88

Journal Abbreviation: Immunology

ISSN: 1365-2567

DAY: 11

MONTH: 01

YEAR: 2008

Cysteine protease cathepsin X modulates immune response via activation of beta2 integrins. Information

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LANGUAGE: eng

NlmUniqueID: 374672

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Grant and Affiliation Information for Cysteine protease cathepsin X modulates immune response via activation of beta2 integrins.

AFFILIATION: Department of Pharmaceutical Biology, Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia.

Country: England

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MEDLINETA: Immunology

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