Cystatin C is not superior to creatinine-based models in estimating glomerular filtration rate in former kidney donors.

Cystatin C is not superior to creatinine-based models in estimating glomerular filtration rate in former kidney donors. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Cystatin C is not superior to creatinine-based models in estimating glomerular filtration rate in former kidney donors. Abstract Text:

Daniel W Louvar,Tyson B Rogers,Robert F Bailey,Arthur J Matas,Hassan N Ibrahim,Daniel W Louvar,Tyson B Rogers,Robert F Bailey,Arthur J Matas,Hassan N Ibrahim,Daniel W Louvar,Tyson B Rogers,Robert F Bailey,Arthur J Matas,Hassan N Ibrahim,Daniel W Louvar,Tyson B Rogers,Robert F Bailey,Arthur J Matas,Hassan N Ibrahim,

BACKGROUND.: The long-term renal consequences of kidney donation need to be accurately quantitated. Cystatin C is a freely filtered glycoprotein that may not have the limitations of creatinine as a measure of glomerular filtration rate (GFR). Whether cystatin C is superior to creatinine-based estimates of GFR in those who have donated a kidney in the past has not been tested. METHODS.: We assessed the performance of seven cystatin C and two creatinine-based GFR prediction equations in 187 former kidney donors against iohexol GFR for measuring GFR. We calculated bias, precision, and relative accuracy of these models. RESULTS.: The majority of former donors had a GFR >60 mL/min/1.73 m. All cystatin C models, except the Rule model, overestimated GFR (range 5.3-31.4 mL/min/1.73 m). Among the cystatin C models, the Hoek and Rule formulas were least biased at 5.3 and -3.8 mL/min/1.73 m, most precise at 0.41, and were within 30% of iohexol GFR, 89.3 and 96% of the time, respectively. The Modification of Diet in Renal Disease (MDRD) formula underestimated GFR by 7.2 mL/min/1.73 m, was most precise (R=0.47) and fell within 30% of measured GFR at the highest frequency of 96%. When all models were given a rank based on their performance in the bias, precision and accuracy domains, the MDRD model was clearly superior. CONCLUSION.: The MDRD equation is superior to cystatin C-based equations for estimating GFR in former kidney donors. Creatinine measurement is cheaper and the MDRD GFR is given out by most laboratories and therefore it should be the preferred model in this population.

Cystatin C is not superior to creatinine-based models in estimating glomerular filtration rate in former kidney donors. Publishing Authors By Initials

DW Louvar,TB Rogers,RF Bailey,AJ Matas,HN Ibrahim,DW Louvar,TB Rogers,RF Bailey,AJ Matas,HN Ibrahim,DW Louvar,TB Rogers,RF Bailey,AJ Matas,HN Ibrahim,DW Louvar,TB Rogers,RF Bailey,AJ Matas,HN Ibrahim,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Cystatin C is not superior to creatinine-based models in estimating glomerular filtration rate in former kidney donors. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Transplantation

VOLUME: 84

Page Numbers: 1112-7

Journal Abbreviation:

ISSN: 0041-1337

DAY: 15

MONTH: Nov

YEAR: 2007

Cystatin C is not superior to creatinine-based models in estimating glomerular filtration rate in former kidney donors. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 132144

Cystatin C is not superior to creatinine-based models in estimating glomerular filtration rate in former kidney donors. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Cystatin C is not superior to creatinine-based models in estimating glomerular filtration rate in former kidney donors. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Cystatin C is not superior to creatinine-based models in estimating glomerular filtration rate in former kidney donors.

AFFILIATION: 1 Division of Renal Diseases and Hypertension, Minneapolis, MN. 2 Department of Surgery, University of Minnesota, Minneapolis, MN.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Transplantation

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Cystatin C is not superior to creatinine-based models in estimating glomerular filtration rate in former kidney donors Related Publications

• A note on permutation tests for variance components in multilevel generalized linear mixed models.
• A temporal hidden Markov regression model for the analysis of gene regulatory networks.
• Building an epidemiological focus in health administration programs: Penn State's experience.
• Co-introgression of Y-chromosome haplogroups and the sickle cell gene across Africa's Sahel.
• Cystatin C is not superior to creatinine-based models in estimating glomerular filtration rate in former kidney donors.
• Dermatofibrosarcoma protuberans in a patient with X-linked agammaglobulinaemia.
• Development of tilt table with visual feedback function for hemiplegia patients.
• Electric field measurements and computational modeling at ultrahigh-field MRI.
• Gender differences in 30-day mortality for patients hospitalized with acute pulmonary embolism.
• Gene expression profile of oral squamous cell carcinomas from Sri Lankan betel quid users.
• Hepatitis C virus infection among patients on hemodialysis in jeddah: a single center experience.
• Identifying risk factors for two complication types for neonatal intensive care patients (NICU).
• Increased Apoptosis and Proliferative Capacity are Early Events in Cyst Formation in Autosomal-Dominant, Polycystic Kidney Disease.
• Magnetic resonance imaging of the spine: An initial experience.
• Mild cognitive impairment.
• Milk conjugated linoleic acid response to fish oil and sunflower oil supplementation to dairy cows managed under two feeding systems.
• Multidrug resistance to Mycobacterium tuberculosis in a tertiary hospital.
• Native and modified lactate dehydrogenase expression in a fumaric acid producing isolate Rhizopus oryzae 99-880.
• OP25.16: 13-14 weeks fetal anatomy scan by transabdominal and transvaginal sonography: obstacles and benefits.
• Optimization of a myeloid cell transfusion strategy for infected neutropenic hosts.
• Performance assessment of broiler chickens given mushroom extract alone or in combination with probiotics.
• Plasmids for expression of heterologous proteins in Rhizopus oryzae.
• Racial and ethnic disparities in hip and knee joint replacement: a review of research in the Veterans Affairs Health Care System.
• Recanalization of systemic venous baffles by radiofrequency perforation and stent implantation.
• Risk Factors for Developing End--Stage-Renal-Failure among Diabetic Patients: A Retrospective Analysis.
• Root and canal morphology of permanent mandibular molars in a Sudanese population.
• Sexually transmitted diseases in domestic expatriate workers in Jeddah, Saudi Arabia.
• The Veterans Health Administration: a domestic model for a national health care system?
• The pattern and outcome of burn injuries at a burn unit in Saudi Arabia: Retrospective analysis of consecutive 501 patients.
• Use of the levator muscle as a frontalis sling.