CysLT2 receptors interact with CysLT1 receptors and down-modulate cysteinyl leukotriene dependent mitogenic responses of mast cells.

CysLT2 receptors interact with CysLT1 receptors and down-modulate cysteinyl leukotriene dependent mitogenic responses of mast cells. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

CysLT2 receptors interact with CysLT1 receptors and down-modulate cysteinyl leukotriene dependent mitogenic responses of mast cells. Abstract Text:

Yongfeng Jiang,Laura A Borrelli,Yoshihide Kanaoka,Brian J Bacskai,Joshua A Boyce,Yongfeng Jiang,Laura A Borrelli,Yoshihide Kanaoka,Brian J Bacskai,Joshua A Boyce,

Cysteinyl leukotrienes (cys-LTs) induce inflammation through 2 G protein-coupled receptors (GPCRs), CysLT(1) and CysLT(2), which are coexpressed by most myeloid cells. Cys-LTs induce proliferation of mast cells (MCs), transactivate c-Kit, and phosphorylate extracellular signal-regulated kinase (ERK). Although MCs express CysLT(2), their responses to cys-LTs are blocked by antagonists of CysLT(1). We demonstrate that CysLT(2) interacts with CysLT(1), and that knockdown of CysLT(2) increases CysLT(1) surface expression and CysLT(1)-dependent proliferation of cord blood-derived human MCs (hMCs). Cys-LT-mediated responses were absent in MCs from mice lacking CysLT(1) receptors, but enhanced by the absence of CysLT(2) receptors. CysLT(1) and CysLT(2) receptors colocalized to the plasma membranes and nuclei of a human MC line, LAD2. Antibody-based fluorescent lifetime imaging microscopy confirmed complexes containing both receptors based on fluorescence energy transfer. Negative regulation of CysLT(1)-induced mitogenic signaling responses of MCs by CysLT(2) demonstrates physiologically relevant functions for GPCR heterodimers on primary cells central to inflammation.

CysLT2 receptors interact with CysLT1 receptors and down-modulate cysteinyl leukotriene dependent mitogenic responses of mast cells. Publishing Authors By Initials

Y Jiang,LA Borrelli,Y Kanaoka,BJ Bacskai,JA Boyce,Y Jiang,LA Borrelli,Y Kanaoka,BJ Bacskai,JA Boyce,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

CysLT2 receptors interact with CysLT1 receptors and down-modulate cysteinyl leukotriene dependent mitogenic responses of mast cells. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Blood

VOLUME: 110

Page Numbers: 3263-70

Journal Abbreviation: Blood

ISSN: 0006-4971

DAY: 10

MONTH: 08

YEAR: 2007

CysLT2 receptors interact with CysLT1 receptors and down-modulate cysteinyl leukotriene dependent mitogenic responses of mast cells. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7603509

CysLT2 receptors interact with CysLT1 receptors and down-modulate cysteinyl leukotriene dependent mitogenic responses of mast cells. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: CysLT2 receptors interact with CysLT1 receptors and down-modulate cysteinyl leukotriene dependent mitogenic responses of mast cells. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for CysLT2 receptors interact with CysLT1 receptors and down-modulate cysteinyl leukotriene dependent mitogenic responses of mast cells.

AFFILIATION: Department of Medicine, Harvard Medical School, Boston, MA, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL 36110

ACRONYM: HL

MEDLINETA: Blood

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

CysLT2 receptors interact with CysLT1 receptors and down-modulate cysteinyl leukotriene dependent mitogenic responses of mast cells Related Publications

• Assessment of an automated bioreactor to propagate and harvest keratinocytes for fabrication of engineered skin substitutes.
• Changes in education.
• Children's memory for a mild stressor: the role of sympathetic activation and parasympathetic withdrawal.
• Chiral building blocks: enantioselective syntheses of benzyloxymethyl phenyl propionic acids.
• CysLT2 receptors interact with CysLT1 receptors and down-modulate cysteinyl leukotriene dependent mitogenic responses of mast cells.
• Decoration of Pasteurella multocida lipopolysaccharide with phosphocholine is important for virulence.
• Determination of additives and organic contaminants in food by CE and CEC.
• Earth monitoring: Vigilance is not enough.
• Fiber density of electrospun gelatin scaffolds regulates morphogenesis of dermal-epidermal skin substitutes.
• High cut-off point membranes in septic acute renal failure: A systematic review.
• Individual and collective exposure to political violence: Palestinian adolescents coping with conflict.
• Influence of electrospun collagen on wound contraction of engineered skin substitutes.
• Injury in Canadian youth: a brief report from the Health Behaviour in School-Aged Children Survey.
• Landscape heterogeneity shapes predation in a newly restored predator-prey system.
• Lysophospholipids as mediators of immunity.
• NF-kappaB p50 and p52 regulate receptor activator of NF-kappaB ligand (RANKL) and tumor necrosis factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1.
• Novel vascular lesions in mice given a non-Peptide vitronectin receptor antagonist.
• Objectives in the Programming of Post-war Sanitation Works.
• Pattern transformation triggered by deformation.
• Preliminary Report of the Sub-Committee on Educational Qualifications of Public Health Engineers.
• Preliminary Report of the Sub-Committee on Educational Qualifications of Sanitarians.
• Restructuring the multi-professional organization: professional identity and adjustment to change in a public hospital.
• Social stratification, health, and violence in the very young.
• Survival of skin graft in mycosis fungoides - a solution for a management dilemma.
• Synthesis of chiral building blocks for use in drug discovery.
• The tao of conscience: conflict and resolution.
• Thyroid function testing in elephant seals in health and disease.
• Willow on Yellowstone's northern range: evidence for a trophic cascade?
• [OBSERVATIONS ON FLUORIDATION OF WATER.]
• [Professional aspects of engineering.]