Cyclosporin a aerosol improves the anticancer effect of Paclitaxel aerosol in mice.

Cyclosporin a aerosol improves the anticancer effect of Paclitaxel aerosol in mice. Research Abstract Details 

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Cyclosporin a aerosol improves the anticancer effect of Paclitaxel aerosol in mice. Abstract Text:

Vernon Knight,N V Koshkina,E Golunski,L E Roberts,B E Gilbert,

Paclitaxel (PTX) is a lipophilic agent with broad anticancer activity. In the present study we examined the antitumor effect and toxicity of co-administration of cyclosporine A (CsA) and PTX in liposomal aerosol using the Renca lung metastases mouse model. The untreated and PTX-only groups exhibited cancer growth while CsA aerosol plus PTX had more favorable effects on tumor growth. Weight loss was seen in mice treated with CsA/PTX+CsA by day 9 to 22. Histopathological examination showed no toxicity following treatment. The findings offer evidence that a combination of CsA and PTX may be suitable for aerosol treatment of lung cancer if it is possible to control toxicity of the therapy.

Cyclosporin a aerosol improves the anticancer effect of Paclitaxel aerosol in mice. Publishing Authors By Initials

V Knight,NV Koshkina,E Golunski,LE Roberts,BE Gilbert,

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Cyclosporin a aerosol improves the anticancer effect of Paclitaxel aerosol in mice. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Transactions of the American Clinical and Climatol

VOLUME: 115

Page Numbers: 395-404

Journal Abbreviation: Trans. Am. Clin. Climatol. Ass

ISSN: 0065-7778

DAY: 24

MONTH: 10

YEAR: 2004

Cyclosporin a aerosol improves the anticancer effect of Paclitaxel aerosol in mice. Information

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LANGUAGE: eng

NlmUniqueID: 7507559

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Country: United States

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MEDLINETA: Trans Am Clin Climatol Assoc

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