Cyclophilin C-associated protein is up-regulated during wound healing.

Cyclophilin C-associated protein is up-regulated during wound healing. Research Abstract Details 

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Cyclophilin C-associated protein is up-regulated during wound healing. Abstract Text:

Wuyi Kong,Shaowei Li,Michael T Longaker,H Peter Lorenz,

Cyclophilin C-associated protein (CyCAP) is identified from macrophages. It locates in intracellular, membrane bound and extracellular, suggesting it has an important role, however both of its regulation and function have not been elucidated. The expression of CyCAP in skin and during wound healing is also unknown. We demonstrate that CyCAP is expressed in both dermal fibroblasts and keratinocytes. In the dermis, the majority of CyCAP protein is located intracellular in a filamentous protein form while a lesser amount is in the extracellular matrix (ECM). CyCAP gene and protein expression is increased 1 day after skin wound healing in both fetal and adult rats and remains elevated level up to 1 week in adult rats. Immunohistochemistry studies demonstrate that the increased CyCAP expression locates mainly to inflammatory cells, including macrophages, monocytes and lymphocytes during wound healing. Interferon-gamma increases CyCAP gene and protein expression in cultured rat fibroblasts. We also found that wound healing is slower and less collagen is expressed in skin of CyCAP null mice. These data are the first observations of CyCAP expression in skin and during wound repair. Our data indicates that CyCAP is regulated by IFNgamma and may function on immune defense in macrophages, lymphocytes, dermal fibroblasts and keratinocytes during wound healing.

Cyclophilin C-associated protein is up-regulated during wound healing. Publishing Authors By Initials

W Kong,S Li,MT Longaker,HP Lorenz,

For similar biological phenomena, cell phenomena, and immunity: biological phenomena: regeneration: wound healing research abstracts see: biological phenomena, cell phenomena, and immunity: biological phenomena: regeneration: wound healing research

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Cyclophilin C-associated protein is up-regulated during wound healing. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of cellular physiology

VOLUME: 210

Page Numbers: 153-60

Journal Abbreviation: J. Cell. Physiol.

ISSN: 0021-9541

DAY: 3

MONTH: Jan

YEAR: 2007

Cyclophilin C-associated protein is up-regulated during wound healing. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 50222

Cyclophilin C-associated protein is up-regulated during wound healing. Keywords Mesh Terms:

KEYWORDS: Wound Healing

MESH TERMS: drug effects

Chemical & Substance for Abstract: Cyclophilin C-associated protein is up-regulated during wound healing. Information

Substance Name: Collagen

Registry Number: 9007-34-5

Grant and Affiliation Information for Cyclophilin C-associated protein is up-regulated during wound healing.

AFFILIATION: Children's Surgical Research Program, Stanford University School of Medicine, Stanford, California 94305, USA.

Country: United States

AGENCY: United States NIDCR

GRANT: DE00463

ACRONYM: DE

MEDLINETA: J Cell Physiol

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