Cyclooxygenase-2 expression on ifosfamide-induced hemorrhagic cystitis in rats.

Cyclooxygenase-2 expression on ifosfamide-induced hemorrhagic cystitis in rats. Research Abstract Details 

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Cyclooxygenase-2 expression on ifosfamide-induced hemorrhagic cystitis in rats. Abstract Text:

Francisco Yuri Bulcao Macedo, Baltazar,Paulo Roberto Carvalho Almeida, ,Francisco Valdeci Ferreira,Fernando C Schmitt,Gerly Anne Castro Brito,Ronaldo Albuquerque Ribeiro,

PURPOSE: Hemorrhagic cystitis (HC) is a limiting side effect of chemotherapy with ifosfamide (IFS). In this study, we investigated the participation of cyclooxygenase-2 (COX-2) upon ifosfamide-induced HC. METHODS: Male Wistar rats (150-200 g; six rats per group) were treated with saline, IFS (400 mg/kg, i.p.) and analyzed by changes in bladder wet weight, macroscopic and microscopic parameters, and COX-2 expression. In other groups etoricoxib (selective COX-2 inhibitor), indomethacin (non-selective COX inhibitor), thalidomide (selective TNF-alpha inhibitor), pentoxifyllin (non-selective TNF-alpha inhibitor) were added 1 h before IFS administration. The classical protocol using three doses of Mesna was also evaluated and compared with two extra doses of etoricoxib or indomethacin. RESULTS: COX-2 was expressed significantly 24 h after IFS administration mainly in myofibroblasts and mast cells evaluated by immunohistochemistry. Treatment 1 h before IFS injection with etoricoxib, indomethacin, thalidomide, and pentoxifylline reduced COX-2 expression and some macroscopic and microscopic parameters in IFS-induced HC. Moreover, addition of etoricoxib or indomethacin with the last two doses of Mesna was more efficient than three doses of Mesna alone when evaluated microscopically. CONCLUSIONS: COX-2 participates in the pathogenesis of IFS-induced HC and the treatment with COX and TNF-alpha inhibitors reduced COX-2 expression. The addition of COX-inhibitors to the last two doses of Mesna represents a new therapeutic strategy of preventing HC.

Cyclooxygenase-2 expression on ifosfamide-induced hemorrhagic cystitis in rats. Publishing Authors By Initials

FY Macedo,F Baltazar,PR Almeida,F ,FV Ferreira,FC Schmitt,GA Brito,RA Ribeiro,

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Cyclooxygenase-2 expression on ifosfamide-induced hemorrhagic cystitis in rats. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of cancer research and clinical oncology

VOLUME: 134

Page Numbers: 19-27

Journal Abbreviation: J. Cancer Res. Clin. Oncol.

ISSN: 0171-5216

DAY: 19

MONTH: 07

YEAR: 2007

Cyclooxygenase-2 expression on ifosfamide-induced hemorrhagic cystitis in rats. Information

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LANGUAGE: eng

NlmUniqueID: 7902060

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AFFILIATION: Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceara, Rua Coronel Nunes de Melo, 1315, Rofolfo Teofilo, 60430-270, Fortaleza, CE, Brazil, yuribulcao@gmail.com.

Country: Germany

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MEDLINETA: J Cancer Res Clin Oncol

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