Cyclin D1 induction of cellular migration requires p27(KIP1).

Cyclin D1 induction of cellular migration requires p27(KIP1). Research Abstract Details 

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Cyclin D1 induction of cellular migration requires p27(KIP1). Abstract Text:

Zhiping Li,Xuanmao Jiao,Chenguang Wang,Xiaoming Ju,Yinan Lu,Liangping Yuan,Michael P Lisanti,Sanjay Katiyar,Richard G Pestell,

The cyclin D1 gene is amplified and overexpressed in human breast cancer, functioning as a collaborative oncogene. As the regulatory subunit of a holoenzyme phosphorylating Rb, cyclin D1 promotes cell cycle progression and a noncatalytic function has been described to sequester the cyclin-dependent kinase inhibitor protein p27. Cyclin D1 overexpression correlates with tumor metastasis and cyclin D1-deficient fibroblasts are defective in migration. The genetic mechanism by which cyclin D1 promotes migration and movement is poorly understood. Herein, cyclin D1 promoted cellular migration and cytokinesis of mammary epithelial cells. Cyclin D1 enhanced cellular migratory velocity. The induction of migration by cyclin D1 was abolished by mutation of K112 or deletion of NH(2)-terminal residues 46 to 90. These mutations of cyclin D1 abrogated physical interaction with p27(KIP1). Cyclin D1(-/-) cells were p27(KIP1) deficient and the defect in migration was rescued by p27(KIP1) reintroduction. Conversely, the cyclin D1 rescue of cyclin D1(-/-) cellular migration was reversed by p27(KIP1) small interfering RNA. Cyclin D1 regulated p27(KIP1) abundance at the posttranslational level, inhibiting the Skp2 promoter, Skp2 abundance, and induced p27(KIP1) phosphorylation at Ser(10). Together, these studies show cyclin D1 promotes mammary epithelial cell migration. p27(KIP1) is required for cyclin D1-mediated cellular migration.

Cyclin D1 induction of cellular migration requires p27(KIP1). Publishing Authors By Initials

Z Li,X Jiao,C Wang,X Ju,Y Lu,L Yuan,MP Lisanti,S Katiyar,RG Pestell,

For similar genetic structures: plasmids research abstracts see: genetic structures: plasmids research

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Cyclin D1 induction of cellular migration requires p27(KIP1). Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cancer research

VOLUME: 66

Page Numbers: 9986-94

Journal Abbreviation: Cancer Res.

ISSN: 0008-5472

DAY: 15

MONTH: Oct

YEAR: 2006

Cyclin D1 induction of cellular migration requires p27(KIP1). Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2984705

Cyclin D1 induction of cellular migration requires p27(KIP1). Keywords Mesh Terms:

KEYWORDS: Plasmids

MESH TERMS: genetics

Chemical & Substance for Abstract: Cyclin D1 induction of cellular migration requires p27(KIP1). Information

Substance Name: Cyclin-Dependent Kinase Inhibitor p27

Registry Number: 147604-94-2

Grant and Affiliation Information for Cyclin D1 induction of cellular migration requires p27(KIP1).

AFFILIATION: Kimmel Cancer Center, Departments of Cancer Biology and Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

Country: United States

AGENCY: United States NCI

GRANT: R01CA75503

ACRONYM: CA

MEDLINETA: Cancer Res

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