Cyclic tetrapeptides via the ring contraction strategy: chemical techniques useful for their identification.

Cyclic tetrapeptides via the ring contraction strategy: chemical techniques useful for their identification. Research Abstract Details 

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Cyclic tetrapeptides via the ring contraction strategy: chemical techniques useful for their identification. Abstract Text:

Douglas A Horton,Gregory T Bourne,Justin Coughlan,Sonya M Kaiser,Carolyn M Jacobs,Alun Jones,Andreas ,Jill Y Turner,Mark L Smythe,

Cyclic tetrapeptides are a class of natural products that have been shown to have broad ranging biological activities and good pharmacokinetic properties. In order to synthesise these highly strained compounds a ring contraction strategy had previously been reported. This strategy was further optimised and a suite of techniques, including the Edman degradation and mass spectrometry/mass spectrometry, were developed to enable characterisation of cyclic tetrapeptide isomers. An NMR solution structure of a cyclic tetrapeptide was also generated. To illustrate the success of this strategy a library of cyclic tetrapeptides was synthesised.

Cyclic tetrapeptides via the ring contraction strategy: chemical techniques useful for their identification. Publishing Authors By Initials

DA Horton,GT Bourne,J Coughlan,SM Kaiser,CM Jacobs,A Jones,A ,JY Turner,ML Smythe,

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Cyclic tetrapeptides via the ring contraction strategy: chemical techniques useful for their identification. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Organic & biomolecular chemistry

VOLUME: 6

Page Numbers: 1386-95

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ISSN: 1477-0520

DAY: 28

MONTH: 02

YEAR: 2008

Cyclic tetrapeptides via the ring contraction strategy: chemical techniques useful for their identification. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Cyclic tetrapeptides via the ring contraction strategy: chemical techniques useful for their identification.

AFFILIATION: Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Qld 4072, Australia. m.smythe@imb.uq.edu.au.

Country: England

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MEDLINETA: Org Biomol Chem

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