Cycad exposure and risk of dementia, MCI, and PDC in the Chamorro population of Guam.

Cycad exposure and risk of dementia, MCI, and PDC in the Chamorro population of Guam. Research Abstract Details 

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Cycad exposure and risk of dementia, MCI, and PDC in the Chamorro population of Guam. Abstract Text:

OBJECTIVE: To study cycad-derived products as possible risk factors for dementia, mild cognitive impairment (MCI), and parkinsonism-dementia complex (PDC) on Guam. METHODS: Complete risk factor data from in-person interviews of 166 cases of Guam dementia, 50 cases of amnestic MCI, and 21 cases of PDC were compared with 1,581 controls in the base population regarding exposure to cycad-derived products from a traditional food (fadang), consumption of fruit bats, and use of cycad-derived topical medicine. RESULTS: Adjusted odds ratios (ORs) and 95% CIs for picking, processing, and eating fadang in young adulthood ranged from 1.42 (1.05 to 1.91) to 2.87 (1.48 to 5.56) and were consistently elevated and significant across all three diagnostic outcomes. Associations independent of exposure in young adulthood were for picking (OR 0.78, 95% CI 0.64 to 0.96) and processing (OR 0.77, 95% CI 0.63 to 0.94) fadang in childhood with Guam dementia. Men showed stronger and more consistent relations across exposure groups in young adulthood compared with women. No associations were found for consumption of fruit bats or exposure to cycad used as a topical medicine for any of the outcomes. Estimated adjusted population attributable risks suggest that exposure to eating fadang in young adulthood incurred the highest attributable risk percent. CONCLUSIONS: Environmental lifestyle and diet may contribute to the etiology of neurodegenerative diseases in the native population of Guam.

Cycad exposure and risk of dementia, MCI, and PDC in the Chamorro population of Guam. Publishing Authors By Initials

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Cycad exposure and risk of dementia, MCI, and PDC in the Chamorro population of Guam. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Neurology

VOLUME: 68

Page Numbers: 1764-71

Journal Abbreviation: Neurology

ISSN: 1526-632X

DAY: 22

MONTH: May

YEAR: 2007

Cycad exposure and risk of dementia, MCI, and PDC in the Chamorro population of Guam. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 401060

Cycad exposure and risk of dementia, MCI, and PDC in the Chamorro population of Guam. Keywords Mesh Terms:

KEYWORDS: Time

MESH TERMS: adverse effects

Chemical & Substance for Abstract: Cycad exposure and risk of dementia, MCI, and PDC in the Chamorro population of Guam. Information

Substance Name: Plant Extracts

Registry Number: 0

Grant and Affiliation Information for Cycad exposure and risk of dementia, MCI, and PDC in the Chamorro population of Guam.

AFFILIATION: Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, FL 33612-3805, USA. aborenst@health.usf.edu

Country: United States

AGENCY: United States NIA

GRANT: P01 AG014382-10

ACRONYM: AG

MEDLINETA: Neurology

REFSOURCE: Neurology. 2007 May 22;68(21):1759-61

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