CXCR5+ CCR7- CD8 T cells are early effector memory cells that infiltrate tonsil B cell follicles.

CXCR5+ CCR7- CD8 T cells are early effector memory cells that infiltrate tonsil B cell follicles. Research Abstract Details 

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CXCR5+ CCR7- CD8 T cells are early effector memory cells that infiltrate tonsil B cell follicles. Abstract Text:

Quigley,Veronica D Gonzalez,Anna Granath,Jan Andersson,Johan K Sandberg, Quigley,Veronica D Gonzalez,Anna Granath,Jan Andersson,Johan K Sandberg,

Naive and central memory CD8 T cells use CCR7 to recirculate through T cell zones of secondary lymphoid organs where they can encounter antigen. Here we describe a subset of human CD8 T cells expressing CXCR5 which enables homing in response to CXCL13 produced within B cell follicles. CXCR5+ CD8 T cells were found in tonsil B cell follicles, and isolated cells migrated towards CXCL13 in vitro. They expressed CD27, CD28, CD45RO, CD69, and were CD7low, and produced IFN-gamma and granzyme A but lacked perforin, a functional profile suggesting that these cells are early effector memory cells in the context of contemporary T cell differentiation models. Receptors important in the interaction with B cells, including CD70, OX40 and ICOS, were induced upon activation, and CXCR5+ CD8 T cells could to some extent support survival and IgG production in tonsil B cells. Furthermore, CXCR5+ CD8 T cells expressed CCR5 but no CCR7, suggesting a migration pattern distinct from that of follicular CD4 T cells. The finding that a subset of early effector memory CD8 T cells use CXCR5 to locate to B cell follicles indicates that MHC class I-restricted CD8 T cells are part of the follicular T cell population.

CXCR5+ CCR7- CD8 T cells are early effector memory cells that infiltrate tonsil B cell follicles. Publishing Authors By Initials

MF Quigley,VD Gonzalez,A Granath,J Andersson,JK Sandberg,MF Quigley,VD Gonzalez,A Granath,J Andersson,JK Sandberg,

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CXCR5+ CCR7- CD8 T cells are early effector memory cells that infiltrate tonsil B cell follicles. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: European journal of immunology

VOLUME: 37

Page Numbers: 3352-62

Journal Abbreviation: Eur. J. Immunol.

ISSN: 0014-2980

DAY: 6

MONTH: Dec

YEAR: 2007

CXCR5+ CCR7- CD8 T cells are early effector memory cells that infiltrate tonsil B cell follicles. Information

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LANGUAGE: eng

NlmUniqueID: 1273201

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Grant and Affiliation Information for CXCR5+ CCR7- CD8 T cells are early effector memory cells that infiltrate tonsil B cell follicles.

AFFILIATION: Center for Infection Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.

Country: Germany

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MEDLINETA: Eur J Immunol

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