CXCL12/CXCR4 expression in trophoblasts takes part in materno-fetal immune tolerance and vascular remodeling.

CXCL12/CXCR4 expression in trophoblasts takes part in materno-fetal immune tolerance and vascular remodeling. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

CXCL12/CXCR4 expression in trophoblasts takes part in materno-fetal immune tolerance and vascular remodeling. Abstract Text:

Yun Yang,Li Zou,Mei Li,Yin Zhao,

In this study, we investigated the expression of CXCL12 (SDF-1)/CXCR4 in trophoblasts and the role they play in the gestation. Immunochemistry was used to detect the expression of CXCR4 and CXCL12 in human villi and placenta. Highly purified extra-villous trophoblasts (EVTs) ere detected for CXCR4 and CXCL12 in vitro by immunocytochemistry. The chemotaxis of CXCL12 was tested in transwell and the chemotactic activity was quantitatively examined. It was suggested that both CXCR4 and CXCL12 were expressed in trophoblasts and were decreased with the gestation time P < 0.05). In a certain coverage, CXCL12 exhibited chemotactic activity which was positively correlated with its concentration [(r) = 0.68, P < 0.01], the maximum chemotactic index (CI) was 1.62 +/- 0.12. Our results suggest that interaction between CXCR4 and CXCL12 is involved in materno-fetal immunological tolerance in all three trimesters of gestation and contributes to the invasion of EVTs during pregnancy.

CXCL12/CXCR4 expression in trophoblasts takes part in materno-fetal immune tolerance and vascular remodeling. Publishing Authors By Initials

Y Yang,L Zou,M Li,Y Zhao,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

CXCL12/CXCR4 expression in trophoblasts takes part in materno-fetal immune tolerance and vascular remodeling. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of Huazhong University of Science and Tech

VOLUME: 26

Page Numbers: 466-8

Journal Abbreviation: J. Huazhong Univ. Sci. Technol

ISSN: 1672-0733

DAY: 22

MONTH: 11

YEAR: 2006

CXCL12/CXCR4 expression in trophoblasts takes part in materno-fetal immune tolerance and vascular remodeling. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101169627

CXCL12/CXCR4 expression in trophoblasts takes part in materno-fetal immune tolerance and vascular remodeling. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: CXCL12/CXCR4 expression in trophoblasts takes part in materno-fetal immune tolerance and vascular remodeling. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for CXCL12/CXCR4 expression in trophoblasts takes part in materno-fetal immune tolerance and vascular remodeling.

AFFILIATION: Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

Country: China

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Huazhong Univ Sci Technolog

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

CXCL12/CXCR4 expression in trophoblasts takes part in materno-fetal immune tolerance and vascular remodeling Related Publications

• Cooperation of endoderm-derived BMP2 and extraembryonic ectoderm-derived BMP4 in primordial germ cell generation in the mouse.
• Effect of vitamin E succinate on expression of TGF-beta1, c-Jun and JNK1 in human gastric cancer SGC-7901 cells.
• Roles of Fas signaling pathway in vitamin E succinate-induced apoptosis in human gastric cancer SGC-7901 cells.
• Vascular osteomuscular autograft prefabrication using coral, type I collagen and recombinant human bone morphogenetic protein-2.
• [Acute physiology and chronic health evaluation II system to prevent and treat infection in surgical ICU]
• [An experimental study on the effect of xenogeneic bone combined with human recombinant bone morphogenetic protein-2]
• [Anterior instrumentation for the treatment of tuberculotic spinal deformity]
• [Arthrowand technique under arthroscope in diagnosis and treatment of knee disease]
• [Breast ptosis correction with a knitted polypropylene mesh]
• [Changes in autoantibody against cardiovascular AT1-receptor during development of renovascular hypertension in rats]
• [Characters of uncoupling protein and its relation with obesity]
• [Classification and treatment of asymmetrical breast deformity]
• [Clinical analysis of 44 cases of recurrent thyroid carcinoma]
• [Clinico-pathologic and prognostic studies on lung adenocarcinoma patients under 40 years of age]
• [Comparative study of human fetal and adult bone marrow derived mesenchymal stem cells]
• [Different serum lipid adjustment drugs for the treatment of hyperlipidemic fatty liver]
• [Effects of air pollution from burning coal on respiratory diseases in adults]
• [Expression of protooncogene c-jun, p38 and proliferating cell nuclear antigen in intestinal epithelial cells in rats different development stages]
• [Inhibition of human gastric carcinoma cell growth by vitamin E succinate]
• [Isolation and identification of chemical constituents from Albizia julibrissin Durazz.]
• [Peritoneal lavage cytology in 66 patients with gastric carcinoma]
• [Relationship between endotracheal intubation pattern and nosocomial infection of medical staff during treatment of severe acute respiratory syndrome]
• [Research on embryonic stem cells]
• [State of the art in the study of postburn ischemic/hypoxic injury]
• [Study of autofluorescence spectrum of dilute gastric juice in the diagnosis of gastric carcinoma]
• [Study on the chemical components of edible oil fume in kitchen and its genotoxity on Drosophila]
• [Study on vitamin E succinate inducing apoptosis of human gastric carcinoma cell]
• [Survey of taenia saginata infection in students in Harbin city]
• [The clinical staging and tissue bacterial quantification in the diagnosis of burn wound sepsis]
• [Ultrasonically guided radio-frequency ablation of liver tumors with a clustered electrode: a report of 100 cases]