CX3CR1+ interstitial dendritic cells form a contiguous network throughout the entire kidney.

CX3CR1+ interstitial dendritic cells form a contiguous network throughout the entire kidney. Research Abstract Details 

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CX3CR1+ interstitial dendritic cells form a contiguous network throughout the entire kidney. Abstract Text:

Dendritic cells (DCs) interface innate and adaptive immunity in nonlymphoid organs; however, the exact distribution and types of DC within the kidney are not known. We utilized CX3CR1GFP/+ mice to characterize the anatomy and phenotype of tissue-resident CX3CR1+ DCs within normal kidney. Laser-scanning confocal microscopy revealed an extensive, contiguous network of stellate-shaped CX3CR1+ DCs throughout the interstitial and mesangial spaces of the entire kidney. Intravital microscopy of the superficial cortex showed stationary interstitial CX3CR1+ DCs that continually probe the surrounding tissue environment through dendrite extensions. Flow cytometry of renal CX3CR1+ DCs showed significant coexpression of CD11c and F4/80, high major histocompatibility complex class II and FcR expression, and immature costimulatory but competent phagocytic ability indicative of tissue-resident, immature DCs ready to respond to environment cues. Thus, within the renal parenchyma, there exists little immunological privilege from the surveillance provided by renal CX3CR1+ DCs, a major constituent of the heterogeneous mononuclear phagocyte system populating normal kidney.

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CX3CR1+ interstitial dendritic cells form a contiguous network throughout the entire kidney. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Kidney international

VOLUME: 70

Page Numbers: 591-6

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ISSN: 0085-2538

DAY: 7

MONTH: 06

YEAR: 2006

CX3CR1+ interstitial dendritic cells form a contiguous network throughout the entire kidney. Information

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LANGUAGE: eng

NlmUniqueID: 323470

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Grant and Affiliation Information for CX3CR1+ interstitial dendritic cells form a contiguous network throughout the entire kidney.

AFFILIATION: Division of Nephrology, New York University School of Medicine, New York, New York 10016, USA. soost01@med.nyu.edu

Country: United States

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MEDLINETA: Kidney Int

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