Cutting Edge: TCR-induced NAB2 enhances T cell function by coactivating IL-2 transcription.

Cutting Edge: TCR-induced NAB2 enhances T cell function by coactivating IL-2 transcription. Research Abstract Details 

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Cutting Edge: TCR-induced NAB2 enhances T cell function by coactivating IL-2 transcription. Abstract Text:

Samuel Collins,Lawrence A Wolfraim,Charles G Drake,Maureen R Horton,Jonathan D Powell,

TCR engagement leads to the up-regulation of genetic programs that can both activate and inhibit T cell function. The early growth receptor (Egr) proteins Egr-2 and Egr-3 have recently been identified as TCR-induced negative regulators of T cell function. NAB2 (NGFI-A-binding protein 2) is both a coactivator and a corepressor of Egr-mediated transcription and has been implicated in regulating Schwann cell myelination. In this report we demonstrate that NAB2 is induced by TCR engagement and that its expression is enhanced by the presence of costimulation. The overexpression of NAB2 enhanced IL-2 production while small interfering RNA to NAB2 markedly inhibited IL-2 expression. Mechanistically, we demonstrate that NAB2 enhances IL-2 transcription by acting as a coactivator for Egr-1. Indeed, chromatin immunoprecipitation analysis reveals that NAB2 is recruited to the Egr-1 binding site of the IL-2 promoter. Taken together, our findings identify NAB2 as a novel coactivator of T cell function.

Cutting Edge: TCR-induced NAB2 enhances T cell function by coactivating IL-2 transcription. Publishing Authors By Initials

S Collins,LA Wolfraim,CG Drake,MR Horton,JD Powell,

For similar genetic processes: gene expression: transcription, genetic research abstracts see: genetic processes: gene expression: transcription, genetic research

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Cutting Edge: TCR-induced NAB2 enhances T cell function by coactivating IL-2 transcription. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of immunology (Baltimore, Md. : 1950)

VOLUME: 177

Page Numbers: 8301-5

Journal Abbreviation: J. Immunol.

ISSN: 0022-1767

DAY: 15

MONTH: Dec

YEAR: 2006

Cutting Edge: TCR-induced NAB2 enhances T cell function by coactivating IL-2 transcription. Information

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LANGUAGE: eng

NlmUniqueID: 2985117

Cutting Edge: TCR-induced NAB2 enhances T cell function by coactivating IL-2 transcription. Keywords Mesh Terms:

KEYWORDS: Transcription, Genetic

MESH TERMS: physiology

Chemical & Substance for Abstract: Cutting Edge: TCR-induced NAB2 enhances T cell function by coactivating IL-2 transcription. Information

Substance Name: Repressor Proteins

Registry Number: 0

Grant and Affiliation Information for Cutting Edge: TCR-induced NAB2 enhances T cell function by coactivating IL-2 transcription.

AFFILIATION: Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

Country: United States

AGENCY: United States NCI

GRANT: R01 CA 098109

ACRONYM: CA

MEDLINETA: J Immunol

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