Cutting edge: syntaxin 11 regulates lymphocyte-mediated secretion and cytotoxicity.

Cutting edge: syntaxin 11 regulates lymphocyte-mediated secretion and cytotoxicity. Research Abstract Details 

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Cutting edge: syntaxin 11 regulates lymphocyte-mediated secretion and cytotoxicity. Abstract Text:

Laura N Arneson,Adipong Brickshawana,Colin M Segovis,Renee A Schoon,Christopher J Dick,Paul J Leibson,

Little is known about the regulatory roles of specific soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins in cytotoxic lymphocytes. Recent information suggests that mutations in the SNARE protein syntaxin 11 result in a form of familial hemophagocytic lymphohistiocytosis (FHL). Because genetic abnormalities in key granule components (e.g., perforin) or in regulators of secretion (e.g., Munc13-4) underlie the other identified forms of FHL, we assessed whether syntaxin 11 might also serve a related regulatory role. We determined that syntaxin 11 is expressed in NK cells and activated CTLs and is located in discrete membrane-associated structures in the cytoplasm. Enhanced expression of syntaxin 11 augments the secretion and killing of tumor targets, and suppression of syntaxin 11 expression inhibits these functions. Our data identify and characterize a role for syntaxin 11 in granule exocytosis and in the generation of cell-mediated killing. These results also provide new insights on the mechanisms of hemopoietic dysregulation in FHL.

Cutting edge: syntaxin 11 regulates lymphocyte-mediated secretion and cytotoxicity. Publishing Authors By Initials

LN Arneson,A Brickshawana,CM Segovis,RA Schoon,CJ Dick,PJ Leibson,

For similar cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes: cd8-positive t-lymphocytes: t-lymphocytes, cytotoxic research abstracts see: cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes: cd8-positive t-lymphocytes: t-lymphocytes, cytotoxic research

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Cutting edge: syntaxin 11 regulates lymphocyte-mediated secretion and cytotoxicity. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of immunology (Baltimore, Md. : 1950)

VOLUME: 179

Page Numbers: 3397-401

Journal Abbreviation: J. Immunol.

ISSN: 0022-1767

DAY: 15

MONTH: Sep

YEAR: 2007

Cutting edge: syntaxin 11 regulates lymphocyte-mediated secretion and cytotoxicity. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985117

Cutting edge: syntaxin 11 regulates lymphocyte-mediated secretion and cytotoxicity. Keywords Mesh Terms:

KEYWORDS: T-Lymphocytes, Cytotoxic

MESH TERMS: secretion

Chemical & Substance for Abstract: Cutting edge: syntaxin 11 regulates lymphocyte-mediated secretion and cytotoxicity. Information

Substance Name: Qa-SNARE Proteins

Registry Number: 0

Grant and Affiliation Information for Cutting edge: syntaxin 11 regulates lymphocyte-mediated secretion and cytotoxicity.

AFFILIATION: Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. lnarneson@yahoo.com

Country: United States

AGENCY: United States NCI

GRANT: CA47752

ACRONYM: CA

MEDLINETA: J Immunol

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