Cutting Edge: Plasmacytoid dendritic cells provide innate immune protection against mucosal viral infection in situ.

Cutting Edge: Plasmacytoid dendritic cells provide innate immune protection against mucosal viral infection in situ. Research Abstract Details 

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Cutting Edge: Plasmacytoid dendritic cells provide innate immune protection against mucosal viral infection in situ. Abstract Text:

Jennifer M Lund,Melissa M Linehan,Norifumi Iijima,Akiko Iwasaki,

Dendritic cells (DCs) are powerful APCs capable of activating naive lymphocytes. Of the DC subfamilies, plasmacytoid DCs (pDCs) are unique in that they secrete high levels of type I IFNs in response to viruses but their role in inducing adaptive immunity remains divisive. In this study, we examined the importance of pDCs and their ability to recognize a virus through TLR9 in immunity against genital HSV-2 infection. We show that a low number of pDCs survey the vaginal mucosa at steady state. Upon infection, pDCs are recruited to the vagina and produce large amounts of type I IFNs in a TLR9-dependent manner and suppress local viral replication. Although pDCs are critical in innate defense against genital herpes challenge, adaptive Th1 immunity developed normally in the absence of pDCs. Thus, by way of migrating directly into the peripheral mucosa, pDCs act strictly as innate antiviral effector cells against mucosal viral infection in situ.

Cutting Edge: Plasmacytoid dendritic cells provide innate immune protection against mucosal viral infection in situ. Publishing Authors By Initials

JM Lund,MM Linehan,N Iijima,A Iwasaki,

For similar urogenital system: genitalia: genitalia, female: vagina research abstracts see: urogenital system: genitalia: genitalia, female: vagina research

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Cutting Edge: Plasmacytoid dendritic cells provide innate immune protection against mucosal viral infection in situ. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of immunology (Baltimore, Md. : 1950)

VOLUME: 177

Page Numbers: 7510-4

Journal Abbreviation: J. Immunol.

ISSN: 0022-1767

DAY: 1

MONTH: Dec

YEAR: 2006

Cutting Edge: Plasmacytoid dendritic cells provide innate immune protection against mucosal viral infection in situ. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985117

Cutting Edge: Plasmacytoid dendritic cells provide innate immune protection against mucosal viral infection in situ. Keywords Mesh Terms:

KEYWORDS: Vagina

MESH TERMS: virology

Chemical & Substance for Abstract: Cutting Edge: Plasmacytoid dendritic cells provide innate immune protection against mucosal viral infection in situ. Information

Substance Name: Toll-Like Receptor 9

Registry Number: 0

Grant and Affiliation Information for Cutting Edge: Plasmacytoid dendritic cells provide innate immune protection against mucosal viral infection in situ.

AFFILIATION: Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.

Country: United States

AGENCY: United States NIAID

GRANT: AI 07019

ACRONYM: AI

MEDLINETA: J Immunol

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