Cutting edge: memory CD8 T cell maturation occurs independently of CD8alphaalpha.

Cutting edge: memory CD8 T cell maturation occurs independently of CD8alphaalpha. Research Abstract Details 

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Cutting edge: memory CD8 T cell maturation occurs independently of CD8alphaalpha. Abstract Text:

As memory CD8 T cells form during acute viral infection, several changes in gene expression and function occur, but little is known about the control of this process. It was reported previously that the homodimer CD8alphaalpha was involved in generating IL-7Ralphahigh memory CD8 T cell precursors, and consequently, protective memory CD8 T cells did not form in animals significantly impaired in CD8alphaalpha expression (E8(I)-/- mice). However, the precise contribution of CD8alphaalpha to sustained IL-7Ralpha expression and other memory CD8 T cell-associated changes has not been investigated. We found that IL-7Ralpha expression and generation of memory CD8 T cells that protect against secondary viral infection was considerably normal in E8(I)-/- animals. Interestingly, virus-specific CD4 T cell responses were elevated, and the relative surface levels of CD8alphabeta in activated T cells were reduced in E8(I)-/- mice compared with wild-type animals. Our results indicate that memory CD8 T cell development can occur independently of CD8alphaalpha.

Cutting edge: memory CD8 T cell maturation occurs independently of CD8alphaalpha. Publishing Authors By Initials

For similar animals: animal population groups: animals, inbred strains: mice, inbred strains: mice, inbred c57bl research abstracts see: animals: animal population groups: animals, inbred strains: mice, inbred strains: mice, inbred c57bl research

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Cutting edge: memory CD8 T cell maturation occurs independently of CD8alphaalpha. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of immunology (Baltimore, Md. : 1950)

VOLUME: 175

Page Numbers: 5619-23

Journal Abbreviation: J. Immunol.

ISSN: 0022-1767

DAY: 1

MONTH: Nov

YEAR: 2005

Cutting edge: memory CD8 T cell maturation occurs independently of CD8alphaalpha. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985117

Cutting edge: memory CD8 T cell maturation occurs independently of CD8alphaalpha. Keywords Mesh Terms:

KEYWORDS: Mice, Inbred C57BL

MESH TERMS: physiology

Chemical & Substance for Abstract: Cutting edge: memory CD8 T cell maturation occurs independently of CD8alphaalpha. Information

Substance Name: CD8 antigen, alpha chain

Registry Number: 0

Grant and Affiliation Information for Cutting edge: memory CD8 T cell maturation occurs independently of CD8alphaalpha.

AFFILIATION: Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.

Country: United States

AGENCY: United States NIAID

GRANT: R01 AI 066232-01

ACRONYM: AI

MEDLINETA: J Immunol

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