Cutaneous lupus: insights into pathogenesis and disease classification.

Cutaneous lupus: insights into pathogenesis and disease classification. Research Abstract Details 

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Cutaneous lupus: insights into pathogenesis and disease classification. Abstract Text:

Victoria P Werth,Victoria P Werth,Victoria P Werth,

Skin disease is the second most common manifestation in SLE patients, and a large number of patients have predominantly cutaneous lupus erythematosus. Experimental animal models suggest that modulation of immunologic factors can have a differential impact on the skin relative to the kidney, and therapeutic responses also suggest potential differences in the immunomodulation of skin relative to other organs affected in lupus. There have been recent insights into the etiology of cutaneous LE, including genetic and environmental factors. The growing understanding of the inflammatory cascade includes the role of UV-induction of pro-inflammatory cytokines, chemokines, and adhesion molecules. Apoptosis, necrosis, autoantibodies, plasmacytoid dendritic cells, T cells, B cells, and vascular changes all play a complex interactive role in the process of induction and maintenance of the lesions of cutaneous LE. Scientific efforts are beginning to clarify the pathophysiologic differences between subsets of cutaneous LE, but there are clearly many areas of investigation needed to elucidate the complex mechanisms that culminate in cutaneous LE.

Cutaneous lupus: insights into pathogenesis and disease classification. Publishing Authors By Initials

VP Werth,VP Werth,VP Werth,

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Cutaneous lupus: insights into pathogenesis and disease classification. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Bulletin of the NYU hospital for joint diseases

VOLUME: 65

Page Numbers: 200-4

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ISSN: 1936-9719

DAY: 9

MONTH: 10

YEAR: 2007

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LANGUAGE: eng

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Grant and Affiliation Information for Cutaneous lupus: insights into pathogenesis and disease classification.

AFFILIATION: The University of Pennsylvania and the Philadelphia Veterans Administration Hospital, Department of Dermatology 19104, USA. werth@mail.med.upenn.edu

Country: United States

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MEDLINETA: Bull NYU Hosp Jt Dis

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