Cushing's syndrome in a clinic population with diabetes.

Cushing's syndrome in a clinic population with diabetes. Research Abstract Details 

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Cushing's syndrome in a clinic population with diabetes. Abstract Text:

S Newsome,K Chen,J Hoang,J D Wilson,J M Potter,P E Hickman,

Background: A recent report has suggested that occult Cushing's syndrome (CS) may be present in a significant number of patients with type 2 diabetes mellitus. The aim of this study was to determine whether any patients in our clinic population with diabetes had this condition. Methods: One hundred and seventy-one consecutive overweight attendees at the diabetic clinic were enrolled in a study to assess the presence of occult CS. The initial screen was with the 1 mg overnight dexamethasone suppression test and follow-up testing, where indicated was with a 24 h collection for urine-free cortisol. Results: Thirty-one of 171 patients had a positive result from the overnight dexamethasone suppression test. Follow-up testing with 24 h urine-free cortisol reduced the number of patients with positive results to 3. Two of these were shown to have alcoholic pseudo-CS. The third patient has had several high urine-free cortisol results, in the presence of normal scans of pituitary and adrenals. He has no stigmata of CS and is being observed. Conclusion: Based on the results of our study, there would appear to be little value in screening type 2 diabetics for CS, in the absence of clinical suspicion.

Cushing's syndrome in a clinic population with diabetes. Publishing Authors By Initials

S Newsome,K Chen,J Hoang,JD Wilson,JM Potter,PE Hickman,

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Cushing's syndrome in a clinic population with diabetes. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Internal medicine journal

VOLUME: 38

Page Numbers: 178-82

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ISSN: 1445-5994

DAY: 23

MONTH: 07

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 101092952

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AFFILIATION: Department of Diabetes and Endocrinology, The Canberra Hospital, Canberra, Australian Capital Territory, Australia.

Country: Australia

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MEDLINETA: Intern Med J

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