Curcumin reduces indomethacin-induced damage in the rat small intestine.

Curcumin reduces indomethacin-induced damage in the rat small intestine. Research Abstract Details 

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Curcumin reduces indomethacin-induced damage in the rat small intestine. Abstract Text:

Nageswaran Sivalingam,Raghunath Hanumantharaya,Minnie Faith,Jayasree Basivireddy,K A Balasubramanian,Molly Jacob,Nageswaran Sivalingam,Raghunath Hanumantharaya,Minnie Faith,Jayasree Basivireddy,K A Balasubramanian,Molly Jacob,

Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used in clinical medicine. Their utility is, however, often limited by the adverse effects they produce in the gastrointestinal tract. Oxidative stress has been shown to occur in the small intestine in response to the oral administration of indomethacin, an NSAID commonly used in toxicity studies. In view of this, the effect of curcumin, an agent with anti-oxidant properties, was evaluated on indomethacin-induced small intestinal damage in a rat model. Rats were pretreated with various doses of curcumin (20 mg kg(-1), 40 mg kg(-1) and 80 mg kg(-1)) before administering indomethacin at 20 mg kg(-1). Various parameters of oxidative stress and the extent of small intestinal damage produced by indomethacin, with and without pretreatment with curcumin, were measured. Macroscopic ulceration was found to occur in the small intestine in response to indomethacin. The viability of enterocytes from indomethacin-treated animals was significantly lower than those from control animals. Drug-induced oxidative stress was also evident as seen by increases in the levels of malondialdehyde and protein carbonyl and in activities of pro-oxidant enzymes such as myeloperoxidase and xanthine oxidase in indomethacin-treated rats. Concomitant decreases were seen in the activities of the antioxidant enzymes catalase and glutathione peroxidase in these animals. Pretreatment with curcumin was found to ameliorate these drug-induced changes. Thus, curcumin appears to hold promise as an agent that can potentially reduce NSAID-induced small intestinal damage.

Curcumin reduces indomethacin-induced damage in the rat small intestine. Publishing Authors By Initials

N Sivalingam,R Hanumantharaya,M Faith,J Basivireddy,KA Balasubramanian,M Jacob,N Sivalingam,R Hanumantharaya,M Faith,J Basivireddy,KA Balasubramanian,M Jacob,

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Curcumin reduces indomethacin-induced damage in the rat small intestine. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of applied toxicology : JAT

VOLUME: 27

Page Numbers: 551-60

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ISSN: 0260-437X

DAY: 30

MONTH: 10

YEAR: 2007

Curcumin reduces indomethacin-induced damage in the rat small intestine. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Curcumin reduces indomethacin-induced damage in the rat small intestine.

AFFILIATION: Department of Biochemistry, Christian Medical College, Vellore-632002, Tamil Nadu, India.

Country: England

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MEDLINETA: J Appl Toxicol

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