Cumulative lead dose and cognitive function in adults: a review of studies that measured both blood lead and bone lead.

Cumulative lead dose and cognitive function in adults: a review of studies that measured both blood lead and bone lead. Research Abstract Details 

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Cumulative lead dose and cognitive function in adults: a review of studies that measured both blood lead and bone lead. Abstract Text:

Regina A Shih,Howard Hu,Marc G Weisskopf,Brian S Schwartz,

OBJECTIVE: We review empirical evidence for the relations of recent and cumulative lead dose with cognitive function in adults. DATA SOURCES: A systematic search of electronic databases resulted in 21 environmental and occupational studies from 1996 to 2006 that examined and compared associations of recent (in blood) and cumulative (in bone) lead doses with neurobehavioral outcomes. DATA EXTRACTION: Data were abstracted after consideration of exclusion criteria and quality assessment, and then compiled into summary tables. CONCLUSIONS: At exposure levels encountered after environmental exposure, associations with bio-markers of cumulative dose (mainly lead in tibia) were stronger and more consistent than associations with blood lead levels. Similarly, in studies of former workers with past occupational lead exposure, associations were also stronger and more consistent with cumulative dose than with recent dose (in blood). In contrast, studies of currently exposed workers generally found associations that were more apparent with blood lead levels; we speculate that the acute effects of high, recent dose may mask the chronic effects of cumulative dose. There is moderate evidence for an association between psychiatric symptoms and lead dose but only at high levels of current occupational lead exposure or with cumulative dose in environmentally exposed adults.

Cumulative lead dose and cognitive function in adults: a review of studies that measured both blood lead and bone lead. Publishing Authors By Initials

RA Shih,H Hu,MG Weisskopf,BS Schwartz,

For similar inorganic chemicals: elements: metals, heavy: lead research abstracts see: inorganic chemicals: elements: metals, heavy: lead research

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Cumulative lead dose and cognitive function in adults: a review of studies that measured both blood lead and bone lead. Journal Published:

PUBLICATION TYPE: Review

Journal: Environmental health perspectives

VOLUME: 115

Page Numbers: 483-92

Journal Abbreviation:

ISSN: 0091-6765

DAY: 22

MONTH: 12

YEAR: 2006

Cumulative lead dose and cognitive function in adults: a review of studies that measured both blood lead and bone lead. Information

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LANGUAGE: eng

NlmUniqueID: 330411

Cumulative lead dose and cognitive function in adults: a review of studies that measured both blood lead and bone lead. Keywords Mesh Terms:

KEYWORDS: Lead

MESH TERMS: toxicity

Chemical & Substance for Abstract: Cumulative lead dose and cognitive function in adults: a review of studies that measured both blood lead and bone lead. Information

Substance Name: Lead

Registry Number: 7439-92-1

Grant and Affiliation Information for Cumulative lead dose and cognitive function in adults: a review of studies that measured both blood lead and bone lead.

AFFILIATION: Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20892, USA.

Country: United States

AGENCY: United States NIEHS

GRANT: R01-ES10798

ACRONYM: ES

MEDLINETA: Environ Health Perspect

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