Cumulative inhibition of NK cells and T cells resulting from engagement of multiple inhibitory Ly49 receptors.

Cumulative inhibition of NK cells and T cells resulting from engagement of multiple inhibitory Ly49 receptors. Research Abstract Details 

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Cumulative inhibition of NK cells and T cells resulting from engagement of multiple inhibitory Ly49 receptors. Abstract Text:

Inhibitory receptors specific for MHC class I molecules are expressed on partially overlapping subpopulations of NK cells and memory T cells. A central question pertinent to NK cell development and function is how the combinatorial expression of different receptors with distinct class I specificities affects functional recognition. We therefore studied the quantitative effects resulting from class I engagement of multiple inhibitory Ly49 receptors. We used a transgenic mouse model in which all NK cells and T cells express two different Ly49 receptors with shared class I specificity. Comparisons of cells from these mice with cells from single transgenic mice and wild-type mice revealed that Ly49 receptors cumulatively inhibit lymphocyte effector functions. Multiple Ly49 interactions also had a cumulative impact on NK cell development. The findings suggest that the interactions of inhibitory receptors with class I are interpreted quantitatively rather than as on/off switches. They have intriguing implications concerning NK cell tolerance and reactivity toward cells with extinguished expression of a limited number of class I molecules.

Cumulative inhibition of NK cells and T cells resulting from engagement of multiple inhibitory Ly49 receptors. Publishing Authors By Initials

For similar nutritional and metabolic diseases: metabolic diseases: wasting syndrome research abstracts see: nutritional and metabolic diseases: metabolic diseases: wasting syndrome research

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Cumulative inhibition of NK cells and T cells resulting from engagement of multiple inhibitory Ly49 receptors. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of immunology (Baltimore, Md. : 1950)

VOLUME: 166

Page Numbers: 3002-7

Journal Abbreviation: J. Immunol.

ISSN: 0022-1767

DAY: 1

MONTH: Mar

YEAR: 2001

Cumulative inhibition of NK cells and T cells resulting from engagement of multiple inhibitory Ly49 receptors. Information

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LANGUAGE: eng

NlmUniqueID: 2985117

Cumulative inhibition of NK cells and T cells resulting from engagement of multiple inhibitory Ly49 receptors. Keywords Mesh Terms:

KEYWORDS: Wasting Syndrome

MESH TERMS: immunology

Chemical & Substance for Abstract: Cumulative inhibition of NK cells and T cells resulting from engagement of multiple inhibitory Ly49 receptors. Information

Substance Name: killer cell lectin-like receptor, subfam

Registry Number: 0

Grant and Affiliation Information for Cumulative inhibition of NK cells and T cells resulting from engagement of multiple inhibitory Ly49 receptors.

AFFILIATION: Institute for Virology and Immunobiology, University of Wurzburg, Wurzburg, Germany.

Country: United States

AGENCY: United States NIAID

GRANT: R01-AI35021

ACRONYM: AI

MEDLINETA: J Immunol

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Cumulative inhibition of NK cells and T cells resulting from engagement of multiple inhibitory Ly49 receptors Related Publications

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• Cumulative inhibition of NK cells and T cells resulting from engagement of multiple inhibitory Ly49 receptors.
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• Genomic Ly49A transgenes: basis of variegated Ly49A gene expression and identification of a critical regulatory element.
• Implications of CD94 deficiency and monoallelic NKG2A expression for natural killer cell development and repertoire formation.
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